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Vol. 34 No. 6 (2022): Vol 34 Issue 6

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Docking, Synthesis and Anticancer Activity of 4-(4-(3-(4-Chloro-3-(trifluoromethyl)- phenyl)ureido)phenoxy)-N-(2-morpholinoethyl)picolinamide Derivatives

https://doi.org/10.14233/ajchem.2022.23772
Vanita Marvaniya
Department of Quality Assurance and Pharmaceutical Chemistry, Faculty of Pharmacy, Nootan Pharmacy College, Sankalchand Patel University, S.K. Campus, Kamana Cross Road, Visnagar-384315, India
Hirak V. Joshi
Faculty of Pharmacy, Nootan Pharmacy College, Sankalchand Patel University, S.K. Campus, Kamana Cross Road, Visnagar-384315, India
Ujashkumar A. Shah
Faculty of Pharmacy, Nootan Pharmacy College, Sankalchand Patel University, S.K. Campus, Kamana Cross Road, Visnagar-384315, India
Jayvadan K. Patel
Faculty of Pharmacy, Nootan Pharmacy College, Sankalchand Patel University, S.K. Campus, Kamana Cross Road, Visnagar-384315, India

Corresponding Author(s) : Vanita Marvaniya

vanitapatel512@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 6 (2022): Vol 34 Issue 6

Abstract

A new series of diaryl urea derivatives bearing pyridine moiety were designed, synthesized and evaluated for their biological activity. In this study, we applied the structure-based virtual screening (SBVS) on the high similar sorafenib approved drug, selected from the DrugBank database as well as on a series of derivatives, selected from the literature. Aim was to provide new potent anticancer agents. Analysis was performed using AutoDock VINA tools. Based on the ligand binding energy. Compounds will be synthesized by chlorination of pyridine acid derivative which further coupled with amine and form amide, amide further reaction with aminophenolic moiety and form ether which is react with other aromatic amine using CDI to produce final compound and these compounds characterized by IR, NMR and mass spectroscopic techniques. The synthesized derivatives have been evaluated to their anticancer activity in vitro by MTT assay using MCF-7 cell line. The anticancer activity indicates that compounds C1, C3, C6 and C9 have better anticancer activity.

Keywords

Diaryl urea derivatives Anticancer agents Molecular docking MTT assay
Marvaniya, V., V. Joshi, H., A. Shah, U., & K. Patel, J. (2022). Docking, Synthesis and Anticancer Activity of 4-(4-(3-(4-Chloro-3-(trifluoromethyl)- phenyl)ureido)phenoxy)-N-(2-morpholinoethyl)picolinamide Derivatives. Asian Journal of Chemistry, 34(6), 1457–1464. https://doi.org/10.14233/ajchem.2022.23772
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