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Synthesis, Characterization and Biological Evaluation of Isoxazoles Derived from 3-Aminoacetophenone
Corresponding Author(s) : T. Raj Kumar
Asian Journal of Chemistry,
Vol. 31 No. 4 (2019): Vol 31 Issue 4
Abstract
Isoxazoles were synthesized by condensing different aldehydes with 3-aminoacetophenone coupled to N-methyl piperazines. All the compounds were screened for anticancer activity against human breast cancer cell lines- MCF-7 and MDA-MB-468. The antimycobacterial activity of compounds were assessed against M. tuberculosis using microplate alamar blue assay (MABA). The structures of newly synthesized compounds established on the basis of their m.p., TLC, FTIR, mass and 1H NMR data. The results of antimycobacterial and anticancer studies shows that some of it posses mild to moderate activity against standard. These new synthesized compounds were identified and characterized, demonstrated antitubercular, in vivo efficacy in tumor models like MCF-7 and MDA-MB-468.
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- J. Kumar, G. Chawla, M. Akhtar, K. Sahu, V. Rathore and S. Sahu, Arabian J. Chem., 10, 141 (2017); https://doi.org/10.1016/j.arabjc.2013.04.027.
- K.A. Kumar and P. Jayaroopa, Int. J. Pharm. Chem. Biol. Sci., 3, 294 (2013).
- C.B. Patil, S.K. Mahajan and S.A. Katti, J. Pharm. Sci. Res., 1, 11 (2009).
- M.A. Rahman, Chem. Sci. J., 2011, 29 (2011).
- H. Suwito, Jumina, Mustofa, A.N. Kristanti and N.N.T. Puspaningsih, J. Chem. Pharm. Res., 6, 1076 (2014).
- G. Thirunarayanan, Org. Chem. Ind. J., 12, 1 (2016).
- K.C. Gautam and D.P. Singh, Chem. Sci. Trans., 2, 992 (2013); https://doi.org/10.7598/cst2013.478.
- R Kalirajan, S. Jubie and B. Gowramma, Peertechz J. Med. Chem. Res., 1, 1 (2015).
- L.S.S. Reddy, M. Bhagavanraju and C. Sridhar, Inventi Impact: Med. Chem., 4, 133 (2015).
- L.S.S. Reddy, M. Bhagavanraju and C. Sridhar, J. Chem. Pharm. Res., 7, 211 (2015).
- M.C.S. Lourenço, M,V.N. de Souza, A.C. Pinheiro, M. de L. Ferreira, R.S.B. Gonçalves, T.C.M. Nogueira and M.A. Peralta, ARKIVOC, 181 (2007); https://doi.org/10.3998/ark.5550190.0008.f18.
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References
J. Kumar, G. Chawla, M. Akhtar, K. Sahu, V. Rathore and S. Sahu, Arabian J. Chem., 10, 141 (2017); https://doi.org/10.1016/j.arabjc.2013.04.027.
K.A. Kumar and P. Jayaroopa, Int. J. Pharm. Chem. Biol. Sci., 3, 294 (2013).
C.B. Patil, S.K. Mahajan and S.A. Katti, J. Pharm. Sci. Res., 1, 11 (2009).
M.A. Rahman, Chem. Sci. J., 2011, 29 (2011).
H. Suwito, Jumina, Mustofa, A.N. Kristanti and N.N.T. Puspaningsih, J. Chem. Pharm. Res., 6, 1076 (2014).
G. Thirunarayanan, Org. Chem. Ind. J., 12, 1 (2016).
K.C. Gautam and D.P. Singh, Chem. Sci. Trans., 2, 992 (2013); https://doi.org/10.7598/cst2013.478.
R Kalirajan, S. Jubie and B. Gowramma, Peertechz J. Med. Chem. Res., 1, 1 (2015).
L.S.S. Reddy, M. Bhagavanraju and C. Sridhar, Inventi Impact: Med. Chem., 4, 133 (2015).
L.S.S. Reddy, M. Bhagavanraju and C. Sridhar, J. Chem. Pharm. Res., 7, 211 (2015).
M.C.S. Lourenço, M,V.N. de Souza, A.C. Pinheiro, M. de L. Ferreira, R.S.B. Gonçalves, T.C.M. Nogueira and M.A. Peralta, ARKIVOC, 181 (2007); https://doi.org/10.3998/ark.5550190.0008.f18.
A. Dolly and J.B. Griffiths, Cell and Tissue Culture for Medical Research, John Wiley & Sons, New York, pp. 62-65 (2000).