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Eco-friendly Synthesis of 3-(Aryl)-2,6-diphenylpyrimidin-4(3H)-ones, Ethyl-1-(aryl)-1,6-dihydro-2-(aryl)-6-oxopyrimidine-4-carboxylates and 6-(4-Arylphenyl)-2-isopropylpyrimidin-4(3H)-one
Corresponding Author(s) : Thirumala Chary Maringanti
Asian Journal of Chemistry,
Vol. 31 No. 4 (2019): Vol 31 Issue 4
Abstract
In present communication, we report the synthesis of pyrimidin-4(3H)-one derivatives by microwave irradiation in good yields and less reaction time. All titled compounds were characterized by IR, NMR and Mass spectral analyses.
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- Y. Ju and R.S. Varma, J. Org. Chem., 71, 135 (2006); https://doi.org/10.1021/jo051878h.
- Y. Ju, D. Kumar and R.S. Varma, J. Org. Chem., 71, 6697 (2006); https://doi.org/10.1021/jo061114h.
- http://www.who.int/tdr/diseases/tb/default.htm.
- D.N. Dhar, The Chemistry of Chalcones and Related Compounds, Wiley: New York, p. 5 (1981).
- K.B. Raut and S.H. Wender, J. Org. Chem., 25, 50 (1960); https://doi.org/10.1021/jo01071a015.
- J.H.S. Green, Z.S. Ariyan, H. Suschitzky, D.D. Perrin, A. Chatterjee, B. Chaudhury, G.A. Bottomley, I.H. Coopes, H. Irving, R.D. Gillard, M.S. Gibson, R.D. Topsom, J. Vaughan, L. Garcia, M. Orchin, N. Bacon, S. Brewis, G.E. Usher, E.S. Waight, W. Baker, B.F. Burrows, Ng.Ph. Buu-Hoi, G. Saint-Ruf, W.P. Griffith, J. Lewis and G. Wilkinson, J. Chem. Soc., 2241 (1961); https://doi.org/10.1039/JR9610002241.
- A. Jurasek, V. Knoppava, M. Dandarova, A. Kovac and J. Reinprecht, Tetrahedron, 34, 1883 (1978).
- S.C. Nigam, G.S. Saharia and H.R. Sharma, J. Indian Chem. Soc., 60, 583 (1983).
- J. Baddiley, B. Lythgoe and A.R. Todd, J. Chem. Soc., 318 (1944); https://doi.org/10.1039/jr9440000318.
- K. Noriyuki and M. Hitoshi, Int. Appl. WO, 03,47,564 (2002); Chem. Abstr., 139, 36532c (2003).
- M.K. Jani, B.R. Shah, N.K. Undavia and P.B. Trivedi, Chem. Abstr., 121, 35513p (1994).
- T.V. Safonova, A.F. Keremov and Yu.A. Ershova, Khim. Farm. Zh., 32, 11 (1998); Chem. Abstr., 131, 18975e (1999).
- C. Jean-Damien, B. David, K. Ronald, G. Julian, L. Pan and D. Robert P.C.T. Int Appl., WO 0222,608 (2002); Chem. Abstr., 136, 247584x (2002).
- O. Nakaguti, N. Shimazaki, M. Shimazaki and M. Nakatuka, Eur. Pat. Appl., 168,005 (1986); Chem. Abstr., 1986, vol. 105, p. 191118p.
- V. Papesh and E.F. Schroeder, US Patent 2714559 (1956); Chem. Abstr., 50, 11370 (1956).
- N. Tokutake, British Patent 146836B (1977); Chem. Abstr., 87, 102370 (1977).
- M. Kurono, JP 62,267,272 (1987); Chem. Abstr., 109, 37382t (1988).
- K.A. Gupta, A.K. Saxena, P.C. Jain, P.R. Dua, C.R. Prasad and N. Anand, Indian J. Chem., 22B, 789 (1983).
- H. Gao and J. Zhang, Chem. Eur. J., 18, 2777 (2012); https://doi.org/10.1002/chem.201103924.
References
Y. Ju and R.S. Varma, J. Org. Chem., 71, 135 (2006); https://doi.org/10.1021/jo051878h.
Y. Ju, D. Kumar and R.S. Varma, J. Org. Chem., 71, 6697 (2006); https://doi.org/10.1021/jo061114h.
http://www.who.int/tdr/diseases/tb/default.htm.
D.N. Dhar, The Chemistry of Chalcones and Related Compounds, Wiley: New York, p. 5 (1981).
K.B. Raut and S.H. Wender, J. Org. Chem., 25, 50 (1960); https://doi.org/10.1021/jo01071a015.
J.H.S. Green, Z.S. Ariyan, H. Suschitzky, D.D. Perrin, A. Chatterjee, B. Chaudhury, G.A. Bottomley, I.H. Coopes, H. Irving, R.D. Gillard, M.S. Gibson, R.D. Topsom, J. Vaughan, L. Garcia, M. Orchin, N. Bacon, S. Brewis, G.E. Usher, E.S. Waight, W. Baker, B.F. Burrows, Ng.Ph. Buu-Hoi, G. Saint-Ruf, W.P. Griffith, J. Lewis and G. Wilkinson, J. Chem. Soc., 2241 (1961); https://doi.org/10.1039/JR9610002241.
A. Jurasek, V. Knoppava, M. Dandarova, A. Kovac and J. Reinprecht, Tetrahedron, 34, 1883 (1978).
S.C. Nigam, G.S. Saharia and H.R. Sharma, J. Indian Chem. Soc., 60, 583 (1983).
J. Baddiley, B. Lythgoe and A.R. Todd, J. Chem. Soc., 318 (1944); https://doi.org/10.1039/jr9440000318.
K. Noriyuki and M. Hitoshi, Int. Appl. WO, 03,47,564 (2002); Chem. Abstr., 139, 36532c (2003).
M.K. Jani, B.R. Shah, N.K. Undavia and P.B. Trivedi, Chem. Abstr., 121, 35513p (1994).
T.V. Safonova, A.F. Keremov and Yu.A. Ershova, Khim. Farm. Zh., 32, 11 (1998); Chem. Abstr., 131, 18975e (1999).
C. Jean-Damien, B. David, K. Ronald, G. Julian, L. Pan and D. Robert P.C.T. Int Appl., WO 0222,608 (2002); Chem. Abstr., 136, 247584x (2002).
O. Nakaguti, N. Shimazaki, M. Shimazaki and M. Nakatuka, Eur. Pat. Appl., 168,005 (1986); Chem. Abstr., 1986, vol. 105, p. 191118p.
V. Papesh and E.F. Schroeder, US Patent 2714559 (1956); Chem. Abstr., 50, 11370 (1956).
N. Tokutake, British Patent 146836B (1977); Chem. Abstr., 87, 102370 (1977).
M. Kurono, JP 62,267,272 (1987); Chem. Abstr., 109, 37382t (1988).
K.A. Gupta, A.K. Saxena, P.C. Jain, P.R. Dua, C.R. Prasad and N. Anand, Indian J. Chem., 22B, 789 (1983).
H. Gao and J. Zhang, Chem. Eur. J., 18, 2777 (2012); https://doi.org/10.1002/chem.201103924.