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Vol. 26 No. 8 (2014): Vol 26 Issue 8

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Effect of Ionic Liquid on Separation and Purification of Tea Polyphenols Using Counter Current Chromatography

https://doi.org/10.14233/ajchem.2014.15695
Xiaofen Chen
Key Laboratory of Chemistry of Northwestern Plant Resources, Chinese Academy of Sciences & Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P.R. China ;Graduate University of Chinese Academy of Sciences, Beijing 100049, P.R. China
Xinyi Huang
Key Laboratory of Chemistry of Northwestern Plant Resources, Chinese Academy of Sciences & Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P.R. China
Gaohong Wang
Key Laboratory of Chemistry of Northwestern Plant Resources, Chinese Academy of Sciences & Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P.R. China ;Graduate University of Chinese Academy of Sciences, Beijing 100049, P.R. China
Jia Zhang
Department of Pharmacy, Gansu College of Traditional Chinese Medicine, No. 35, Dingxi East Road, Lanzhou 730000, P.R. China
Duolong Di
Key Laboratory of Chemistry of Northwestern Plant Resources, Chinese Academy of Sciences & Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P.R. China ;Center of Resource Chemical and New Material, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, No. 36, Jinshui Road, Qingdao 266100, P.R. China

Corresponding Author(s) : Duolong Di

didl@licp.cas.cn

Asian Journal of Chemistry, Vol. 26 No. 8 (2014): Vol 26 Issue 8

Abstract

In order to research the effect of ionic liquid as additives in two-phase solvent system on the behaviour of counter-current chromatography and develop more efficient methods of preparative separation and purification for natural products, a series of imidazolium-based ionic liquids with anion of [BF4]– (1-methyl-3-methylimidazolium tetrafluoroborate, 1-ethyl-3-methylimidazolium tetrafluoroborate, 1-propyl-3-methylimidazolium tetrafluoroborate, 1-butyl-3-methylimidazolium tetrafluoroborate) and four structurally similar tea polyphenols ((-)-epigallocatechin-3-gallate, (-)-epicatechin, (-)-epicatechin-3-gallate, (-)-gallocatechin gallate) were, respectively chosen as additives and model molecules. The results showed that with the additive of 0.6 mol/L [MMIM][BF4] in ethyl acetate-water solvent system, the K values of (-)-epicatechin-3-gallate could drop from 30.46 to 3.47. The process of screening solvent systems based on ionic liquids was simpler and more efficiency than traditional ways. Subsequently, IR and NMR spectrum were performed to investigate the interactions between tea polyphenols and ionic liquids. It was considered that the major interaction between ionic liquid and target compounds was electrostatic attraction.

Keywords

Counter current chromatography Ionic liquids Tea polyphenols
Chen, X., Huang, X., Wang, G., Zhang, J., & Di, D. (2014). Effect of Ionic Liquid on Separation and Purification of Tea Polyphenols Using Counter Current Chromatography. Asian Journal of Chemistry, 26(8), 2271–2276. https://doi.org/10.14233/ajchem.2014.15695
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