A New Sesquiterpene from Nicotiana tabacum and Its Cytotoxicity

Yong-Kuan Chen; Chunyang Meng1; Su Zhongbi; Lu Wang; Guangyu-Yu Yang; Ming-Ming Miao

doi:10.14233/ajchem.2014.15680

Issue

Vol. 26 No. 8 (2014): Vol 26 Issue 8

Issue Published : April 15, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

A New Sesquiterpene from Nicotiana tabacum and Its Cytotoxicity

https://doi.org/10.14233/ajchem.2014.15680

Yong-Kuan Chen

Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China

Chunyang Meng1

Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China ;Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities), State Ethnic Affairs Commission & Ministry of Education, Kunming 650031, P.R. China

Su Zhongbi

Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China

Lu Wang

Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China

Guangyu-Yu Yang

Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China

Ming-Ming Miao

Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China

Corresponding Author(s) : Ming-Ming Miao

mmmiao@cyats.com

Asian Journal of Chemistry, Vol. 26 No. 8 (2014): Vol 26 Issue 8
Article Published : April 16, 2014

Abstract

A new sesquiterpene, tabsesquiterpene A (1) was isolated from the leaves of Nicotiana tabacum. Its structure was elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compound 1 was tested for its cytotoxicity. The results showed that 1 exhibited modest cytotoxicity against SHSY5Y, PC3 and MCF7 with IC₅₀ values of 6.9, 4.5 and 8.8 μM, respectively.

Keywords

Nicotiana tabacum Sesquiterpene Cytotoxicity Tabsequiterpene A

Chen, Y.-K., Meng1, C., Zhongbi, S., Wang, L., Yang, G.-Y., & Miao, M.-M. (2014). A New Sesquiterpene from Nicotiana tabacum and Its Cytotoxicity. Asian Journal of Chemistry, 26(8), 2246–2248. https://doi.org/10.14233/ajchem.2014.15680

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References

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References

The Editorial Committee of the Administration Bureau of Flora of China, Flora of China, 67 vols. (Beijing Science and Technology Press, Beijing, (2005).

T.W. Hu and Z. Mao, Tob. Control, 15(suppl_1), i37 (2006); doi:10.1136/tc.2005.014621.

A. Rodgman and T.A. Perfetti, The Chemical Components of Tobacco and Tobacco Smoke, CRC Press, Taylor and Francis Group, Boca Raton, Florida (2008).

A.P. Cavender and M. Alban, J. Ethnobiol. Ethnomed., 5, 3 (2009); doi:10.1186/1746-4269-5-3.

A. Inta, P. Shengji, H. Balslev, P. Wangpakapattanawong and C. Trisonthi, J. Ethnopharmacol., 116, 134 (2008); doi:10.1016/j.jep.2007.12.015.

X. Feng, J.-S. Wang, J. Luo and L.-Y. Kong, J. Asian Nat. Prod. Res., 12, 252 (2010); doi:10.1080/10286020903550947.

Y. Shinozaki, T. Tobita, M. Mizutani and T. Matsuzaki, Biosci. Biotechnol. Biochem., 60, 903 (1996); doi:10.1271/bbb.60.903.

T. Pettersson, A.M. Eklund and I. Wahlberg, J. Agric. Food Chem., 41, 2097 (1993); doi:10.1021/jf00035a052.

X.C. Wei, S.C. Sumithran, A.G. Deaciuc, H.R. Burton, L.P. Bush, L.P. Dwoskin and P.A. Crooks, Life Sci., 78, 495 (2005); doi:10.1016/j.lfs.2005.09.009.

T. Braumann, G. Nicolaus, W. Hahn and H. Elmenhorst, Phytochemistry, 29, 3693 (1990); doi:10.1016/0031-9422(90)85311-3.

Y.K. Chen, X.S. Li, G.Y. Yang, Z.Y. Chen, Q.F. Hu and M.M. Miao, J. Asian Nat. Prod. Res., 14, 450 (2012); doi:10.1080/10286020.2012.669578.

Q.-F. Hu, G. Yang, X. Li, X. Yang, H. Mu, Y. Chen and X.-M. Gao, Heterocycles, 85, 147 (2012); doi:10.3987/COM-11-12349.

Z.Y. Chen, J.L. Tan, G.Y. Yang, M.M. Miao, Z.Y. Chen and T.F. Li, Phytochem. Lett., 5, 233 (2012); doi:10.1016/j.phytol.2012.01.001.

J.L. Tan, Z.Y. Chen, G.Y. Yang, M.M. Miao, Y.K. Chen and T.F. Li, Heterocycles, 83, 2381 (2011); doi:10.3987/COM-11-12317.

R. Liu, K.L. Hsieh and J.K. Liu, Bot. Yunnan, 31, 383 (2005); doi:10.3724/SP.J.1143.2009.09062.

T. Mosmann, J. Immunol. Methods, 65, 55 (1983); doi:10.1016/0022-1759(83)90303-4.

Issue

Vol. 26 No. 8 (2014): Vol 26 Issue 8

A New Sesquiterpene from Nicotiana tabacum and Its Cytotoxicity

Corresponding Author(s) : Ming-Ming Miao

Abstract

Keywords

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