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Synthesis of Novel 2-Amino-benzo[de]isoquinolin-1,3-dione Derivatives
Corresponding Author(s) : R. Al-Salahi
Asian Journal of Chemistry,
Vol. 26 No. 7 (2014): Vol 26 Issue 7
Abstract
From a pioneer bioactive amino-benzoisoquinoline i.e. 2-amino-1H-benzo[de]isoquinolin-1,3-dione, a new series of Schiff's bases were prepared by the reaction of the active 2-amino group with a variety of aryl(hetero)aldehydes, isothiocyanides and acid anhydrides. The success of all reactions has been followed up by characterization of the synthesized target molecules through IR, Mass spectra and NMR analyses. The structural modifications were designed aiming at synthesis of valuable bioactive agents.
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- Y. Xu, B. Qu, X. Qian and Y. Li, Bioorg. Med. Chem. Lett., 15, 1139 (2005); doi:10.1016/j.bmcl.2004.12.011.
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- R. Al-Salahi and D. Geffken, Molecules, 15, 7016 (2010); doi:10.3390/molecules15107016.
- R. Al-Salahi and D. Geffken, Synth. Commun., 41, 3512 (2011); doi:10.1080/00397911.2010.518780.
References
Y. Xu, B. Qu, X. Qian and Y. Li, Bioorg. Med. Chem. Lett., 15, 1139 (2005); doi:10.1016/j.bmcl.2004.12.011.
A. Mukherjee, S. Hazra, S. Dutta, S. Muthiah, D.M. Mondhe, P.R. Sharma, S.K. Singh, A.K. Saxena, G.N. Qazi and U. Sanyal, Invest. New Drugs, 29, 434 (2011); doi:10.1007/s10637-009-9372-z.
M.F. Brana, J.M. Castellano, M. Moran, M.J. Perez de Vega, C.A. Romerdahl, X.D. Qian, P. Bousquet, F. Emling, E. Schlick and G. Keilhauer, Anticancer Drug Des., 8, 257 (1993).
A. Vaisburg, N. Bernstein, S. Frechette, M. Allan, E. Abou-Khalil, S. Leit, O. Moradei, G. Bouchain, J. Wang, S.H. Woo, M. Fournel, P.T. Yan, M.-C. Trachy-Bourget, A. Kalita, C. Beaulieu, Z. Li, A.R. MacLeod, J.M. Besterman and D. Delorme, Bioorg. Med. Chem. Lett., 14, 283 (2004); doi:10.1016/j.bmcl.2003.08.083.
A. Mukherjee, S. Dutta, M. Shanmugavel, D.M. Mondhe, P.R. Sharma, S.K. Singh, A.K. Saxena and U. Sanyal, J. Exp. Clin. Cancer Res., 29, 175 (2010); doi:10.1186/1756-9966-29-175.
A. Wu, J. Liu, S. Qin and P. Mei, Monatsh. Chem., 141, 95 (2010); doi:10.1007/s00706-009-0220-9.
M. Llombart, A. Poveda, E. Forner, C.F. Martos, C. Gaspar, M. Munoz, T. Olmos, A. Ruiz, V. Soriano, A. Benavides, M. Martin, E. Schlick and V. Guillem, Invest. New Drugs, 10, 177 (1992); doi:10.1007/BF00877243.
A. Casado, R. Rosell, R. García-Gómez, E. Díaz-Rubio, G. Pérez-Manga, A. Font, A. Benavides and M. Martín, Invest. New Drugs, 14, 415 (1996); doi:10.1007/BF00180820.
A.N. Leaf, D. Neuberg, E.L. Schwartz, S. Wadler, P.S. Ritch, J.P. Dutcher and G.L. Adams, Invest. New Drugs, 15, 165 (1997); doi:10.1023/A:1005823703909.
K. Bożena, K. Mariola, K. Jerzy, S. Ksenia, K. Marta and M. Grażyna, Heterocycl. Commun., 18, 275 (2012); doi:10.1515/hc-2012-0115.
E. Lacivita, M. Leopoldo, A.C. Masotti, C. Inglese, F. Berardi, R. Perrone, S. Ganguly, M. Jafurulla and A. Chattopadhyay, J. Med. Chem., 52, 7892 (2009); doi:10.1021/jm900706d.
R. Al-Salahi and D. Geffken, Heterocycles, 81, 1843 (2010); doi:10.3987/COM-10-11976.
R. Al-Salahi and D. Geffken, Molecules, 15, 7016 (2010); doi:10.3390/molecules15107016.
R. Al-Salahi and D. Geffken, Synth. Commun., 41, 3512 (2011); doi:10.1080/00397911.2010.518780.