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Vol. 26 No. 4 (2014): Vol 26 Issue 4

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Study on Electrochemical Behaviours and Diffusion Mechanism of Acetaminophen and Dopamine at Pre-Anodized Carbon Paste Electrode

https://doi.org/10.14233/ajchem.2014.15710
Binglin Fan
School of Chemistry and Chemical Engineering, Henan Normal University, Henan Key Laboratory for Environmental Pollution Control, Xinxiang 453007, Henan Province, P.R. China ; 2School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, Henan Province, P.R. China
Enbo Shangguan
School of Chemistry and Chemical Engineering, Henan Normal University, Henan Key Laboratory for Environmental Pollution Control, Xinxiang 453007, Henan Province, P.R. China
Yao Sun
School of Chemistry and Chemical Engineering, Henan Normal University, Henan Key Laboratory for Environmental Pollution Control, Xinxiang 453007, Henan Province, P.R. China
Jing Li
School of Chemistry and Chemical Engineering, Henan Normal University, Henan Key Laboratory for Environmental Pollution Control, Xinxiang 453007, Henan Province, P.R. China
Quanmin Li
School of Chemistry and Chemical Engineering, Henan Normal University, Henan Key Laboratory for Environmental Pollution Control, Xinxiang 453007, Henan Province, P.R. China

Corresponding Author(s) : Quanmin Li

mercury6068@hotmail.com

Asian Journal of Chemistry, Vol. 26 No. 4 (2014): Vol 26 Issue 4

Abstract

A pre-anodized carbon paste electrode (PACPE) was fabricated and used to investigate the electrochemical behaviours of acetaminophen and dopamine. The results indicated that the voltammetric responses of acetaminophen and dopamine were considerably enhanced at PACPE in pH = 7.0 phosphate buffer solution. Furthermore, the diffusion mechanism of the influence on oxidation peak currents of acetaminophen and dopamine has been put forward. The driving force for the diffusion of acetaminophen and dopamine toward anode not only related to concentration diffusion but also involved with transport of H+ in the feed phase along a concentration gradient toward cathode. Under the optimized conditions in linear scan voltammetry technique, acetaminophen and dopamine gave linear response over the range of 2.0 × 10-6-5.0 × 10-4 mol/L, 2.0 × 10-6-4.0 × 10-4 mol/L, respectively. The detection limits (S/N =11) were found to be 0.42 μmol/L for acetaminophen and 0.21 μmol/L for dopamine. The proposed method was successfully applied to the determination of acetaminophen and dopamine in commercial pharmaceutical samples.

Keywords

Acetaminophen Dopamine Diffusion mechanism Pre-anodized carbon paste electrode
Fan, B., Shangguan, E., Sun, Y., Li, J., & Li, Q. (2014). Study on Electrochemical Behaviours and Diffusion Mechanism of Acetaminophen and Dopamine at Pre-Anodized Carbon Paste Electrode. Asian Journal of Chemistry, 26(4), 981–986. https://doi.org/10.14233/ajchem.2014.15710
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