Synthesis and Spectral Investigation (1H and 13C) of Tetradentate Schiff Base Ligands for the Preparation of Post Transition Bimetallic Complexes of Antimicrobial Importance

Ameer Fawad Zahoor; Muhammad Yousaf; Muhammad Pervaiz; Anbreen Anjum; Kulsoom Ghulam Ali; Faisal Maqbool Zahid; Sajjad Ahmad; Shazia Anwer Bukhari; Bushra Parveen

doi:10.14233/ajchem.2014.15834

Issue

Vol. 26 No. 3 (2014): Vol 26 Issue 3

Issue Published : January 30, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Spectral Investigation (1H and 13C) of Tetradentate Schiff Base Ligands for the Preparation of Post Transition Bimetallic Complexes of Antimicrobial Importance

https://doi.org/10.14233/ajchem.2014.15834

Ameer Fawad Zahoor

Department of Chemistry, Government College University, Faisalabad, Pakistan

Muhammad Yousaf

Department of Chemistry, Government College University, Faisalabad, Pakistan

Muhammad Pervaiz

Department of Chemistry, Government College University, Faisalabad, Pakistan

Anbreen Anjum

Department of Applied Chemistry and Biochemistry, Government College University, Faisalabad, Pakistan

Kulsoom Ghulam Ali

Department of Chemistry, Government College University, Faisalabad, Pakistan

Faisal Maqbool Zahid

Department of Statistics, Government College University, Faisalabad, Pakistan

Sajjad Ahmad

University of Engineering and Technology Lahore, Faisalabad Campus, Faisalabad, Pakistan

Shazia Anwer Bukhari

Department of Applied Chemistry and Biochemistry, Government College University, Faisalabad, Pakistan

Bushra Parveen

Department of Chemistry, Government College University, Faisalabad, Pakistan

Corresponding Author(s) : Muhammad Yousaf

dryousafsmor@gmail.com

Asian Journal of Chemistry, Vol. 26 No. 3 (2014): Vol 26 Issue 3
Article Published : January 30, 2014

Abstract

A tetradentate Schiff base ligand 2-(bis-2-hydroxylphenylidene)-1,2-diiminoethanne (L) was synthesized and then its structure was investigated by ¹H NMR and ¹³C NMR techniques. The ligand and its bimetallic complexes were screened in vitro for antibacterial and antifungal activities by using disc diffusion method. The results showed that in case of antibacterial activity the Co₂L₂ exhibited better efficiency (9 ± 0.816) against E. coli while binuclear complex of Mn₂L₂ showed better potential against all the three strains (E. coli, S. aureus and A. alternate) as compared with other attempted bimetallic (Cu, Mn and Zn) complexes when compared with standard one. Similarly the antifungal potential of binuclear (Co₂L₂) complex was satisfactory (12.25 ± 0.062) for A. alternate while the binuclear Cu₂L₂ complex exhibited good effect (7.75 ± 0.957) against A. niger. Similarly binuclear Mn₂L₂ complex showed better efficiency (10.25 ± 0.5) against A. flavous. The biological activity data justified that binuclear post transition metal complexes with Schiff base can be successfully used against fungal as well as bacterial infections.

Keywords

Tetradentate Schiff base Binuclear complexes Bacterial strains Fungal strains

Fawad Zahoor, A., Yousaf, M., Pervaiz, M., Anjum, A., Ghulam Ali, K., Maqbool Zahid, F., … Parveen, B. (2014). Synthesis and Spectral Investigation (1H and 13C) of Tetradentate Schiff Base Ligands for the Preparation of Post Transition Bimetallic Complexes of Antimicrobial Importance. Asian Journal of Chemistry, 26(3), 841–845. https://doi.org/10.14233/ajchem.2014.15834

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References

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References

R. Atkins, G. Brewer, E. Kokot, G.M. Mockler and E. Sinn, Inorg. Chem., 24, 127 (1985); doi:10.1021/ic00196a003.

M. Salavati-Niasari, Z. Salimi, M. Bazarganipour and F. Davar, Inorg. Chim. Acta, 362, 3715 (2009); doi:10.1016/j.ica.2009.04.028.

B. Geeta, K. Shravankumar, P.M. Reddy, E. Ravikrishna, M. Sarangapani, K.K. Reddy and V. Ravinder, Spectrochim. Acta A, 77, 911 (2010); doi:10.1016/j.saa.2010.08.004.

E.A. Elzahany, K.H. Hegab, S.K.H. Khalil and N.F. Youssef, Aust. J. Basic Appl. Sci., 2, 210 (2008).

J. Gold, Nutr. Cancer, 9, 59 (1987); doi:10.1080/01635588709513912.

J. Sun, D.M. Liu, J.X. Wang and C.G. Yan, J. Incl. Phenom. Macrocycl. Chem., 64, 317 (2009); doi:10.1007/s10847-009-9570-5.

P.G. Cozzi, Chem. Soc. Rev., 33, 410 (2004); doi:10.1039/b307853c.

D. Singh, K. Kumar, S.S. Dhiman and J. Sharma, J. Enzyme Inhib. Med. Chem., 25, 21 (2010); doi:10.3109/14756360902932750.

A.D. Logua, V. Onnis, B. Saddi, C. Congiu, M.L. Schivo and M.C. Cocco, J. Antimicrob. Chemother., 49, 275 (2002); doi:10.1093/jac/49.2.275.

M. Cuenca-Estrella, B. Ruiz-Diez, J.V. Martinez-Suarez, A. Monzon and J.L. Rodriguez-Tudela, J. Antimicrob. Chemother., 43, 149 (1999); doi:10.1093/jac/43.1.149.

N. Raman, J.D. Raja and A. Sakthivel, J. Chem. Sci., 119, 303 (2007); doi:10.1007/s12039-007-0041-5.

F. Amel, E.I. Husseiny, E.S. Azam and J.A.l. Shehar, Inorg. Chem.:An Ind. J., 3, 64 (2008).

Issue

Vol. 26 No. 3 (2014): Vol 26 Issue 3

Synthesis and Spectral Investigation (1H and 13C) of Tetradentate Schiff Base Ligands for the Preparation of Post Transition Bimetallic Complexes of Antimicrobial Importance

Corresponding Author(s) : Muhammad Yousaf

Abstract

Keywords

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