Synthesis of Some Novel Thiobarbituric Acid Derivatives and Their Related Compounds from Sulfa-Drug as Antiinflammatory

Mohie Aldin M. Zayed

doi:10.14233/ajchem.2014.15516

Issue

Vol. 26 No. 3 (2014): Vol 26 Issue 3

Issue Published : January 30, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis of Some Novel Thiobarbituric Acid Derivatives and Their Related Compounds from Sulfa-Drug as Antiinflammatory

https://doi.org/10.14233/ajchem.2014.15516

Mohie Aldin M. Zayed

Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi ArabiaCorresponding author: Fax: +966 2 6952292; E-mail:

Corresponding Author(s) : Mohie Aldin M. Zayed

mohiem@yahoo.com

Asian Journal of Chemistry, Vol. 26 No. 3 (2014): Vol 26 Issue 3
Article Published : January 30, 2014

Abstract

In search for new antiinflammatory agents, some new substituted thiobarbituric acids (2) and their bis-fused or fused thiopyrimidinyl-pyrimidinone (7, 8) have been derived from sulfathiazole and dimethylmalonate with CS₂. structures of the synthesized compounds were established by spectroscopic (FT-IR, ¹H NMR, ¹³C NMR, Mass) and elemental analyses. The antiinflammatory activity of these compounds was tested against carrageen-induced oedema with the reference of standard drug phenyl butazone. The results showed that compounds 2 and 3 are better antiinflammatory agents as compared to standard drug phenyl butazone.

Keywords

Synthetic Thiobarbituric Antiinflammatory

Aldin M. Zayed, M. (2014). Synthesis of Some Novel Thiobarbituric Acid Derivatives and Their Related Compounds from Sulfa-Drug as Antiinflammatory. Asian Journal of Chemistry, 26(3), 749–754. https://doi.org/10.14233/ajchem.2014.15516

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References

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References

A. De Logu, V. Omis, B. Saddi, C. Congien and M.L. Schivo, J. Antimicrob. Chemother., 49, 275 (2002); doi:10.1093/jac/49.2.275.

L. Savini, L. Chiasserini, A. Gaeta and C. Pellerano, Bioorg. Med. Chem., 10, 2193 (2002); doi:10.1016/S0968-0896(02)00071-8.

A.M. Asiri and S.A. Khan, Molecules, 15, 4784 (2010); doi:10.3390/molecules15074784.

A. Andreani, M. Granaiola, A. Lemi, A. Locatelli, R. Morigi, M. Rambaldi, G. Giorgi and V. Garaliene, Anticancer Res., 24, 203 (2004).

M.E. Furrow and A.G. Myers, J. Am. Chem. Soc., 126, 436 (2004); doi: 10.1021/ja049694s .

S.A. Khan, N. Singh and K. Saleem, Eur. J. Med. Chem., 43, 2272 (2008); doi:10.1016/j.ejmech.2007.12.012.

G.R. Cook, B.C. Maity and R. Kargbo, Org. Lett., 6, 1741 (2004); doi:10.1021/ol0496172.

A.K. Halve, P. Gour, R. Dubey, D. Bhadauria and B. Bhaskari, J. Indian Chem. Soc., 82, 942 (2005).

A.M. Asiri and S.A. Khan, Molecules, 16, 523 (2011); doi:10.3390/molecules16010523.

R.M. Abdel-Rahman, J.M. Morsy, F. Hanafy and H.A. Amene, Pharmazie, 54, 347 (1999).

R.M. Abdel-Rahman, Pharmazie, 56, 18 (2001).

R.M. Abdel-Rahman, Pharmazie, 56, 195 (2001).

R.M. Abdel-Rahman, Trends Heterocycl. Chem., 8, 187 (2002).

W.R. Abdel-Monem and R.M. Abdel-Rahman, Int. J. Chem., 16, 1 (2006).

M.A. Ibrahim, R.M. Abdel-Rahman, A.M. Abdel-Halim, S.S. Ibrahim and H.A. Allimony, ARKIVOC, 202 (2008); doi:10.3998/ark.5550190.0009.g19.

M.G. Valverde and T. Torroba, Sulfur-Nitrogen Heterocycl. Mol., 10, 318 (2005).

S.M. Abu-El-Wafa, R.M. Abdel-Rahman and Z. El-Gendy, Egypt. J. Chem., 33, 387 (1990).

J.H. Chern, K.S. Shia, C.M. Chang, C.C. Lee, Y.-C. Lee, C.-L. Tai, Y.-T. Lin, C.-S. Chang and H.-Y. Tseng, Bioorg. Med. Chem. Lett., 14, 1169 (2004); doi:10.1016/j.bmcl.2003.12.073.

M. Seada, R.M. Abdel-Rahman and M. Abdel-Megib, Indian J. Heterocycl. Chem., 3, 9 (1993).

T.E. Ali, R.M. Abdel-Rahman, F.I. Hanafy and S.M. El-Edfawy, Phosphorus Sulfur Silicon Rel. Elem., 183, 2577 (2008);doi:10.1080/10426500801967864.

M.A. Ibrahim, R.M. Abdel-Rahman, A.M. Abdel-Halim, S.S. Ibrahim and H.A. Allimony, J. Braz. Chem. Soc., 20, 1275 (2009); doi:10.1590/S0103-50532009000700012.

C.A. Winter, E.A. Risley and G.W. Nuss, Exp. Biol. Med., 111, 544 (1962); doi:10.3181/00379727-111-27849.

P. Ashokkumar and G. Sudhandiran, Biomed. Pharmacother., 62, 590 (2008); doi:10.1016/j.biopha.2008.06.031.

C.A. Winter, E.A. Risley and G.W. Nuss, J. Pharmacol. Exp. Ther., 141, 369 (1963).

R.M. Abdel-Rahman, M.S.T. Makki and W.A. Bawazir, E.-J. Chem., 7, 93 (2010); doi:10.1155/2010/467564.

R.M. Abdel-Rahman, M.S.T. Makki and W.A. Bawazir, E.-J. Chem., 8, 405 (2011); doi:10.1155/2011/586063.

R.M. Abdel-Rahman, K.O. Al-Footy and F.M. Aglan, Int. J. Chem. Tech. Res., 3, 423 (2011).

Issue

Vol. 26 No. 3 (2014): Vol 26 Issue 3

Synthesis of Some Novel Thiobarbituric Acid Derivatives and Their Related Compounds from Sulfa-Drug as Antiinflammatory

Corresponding Author(s) : Mohie Aldin M. Zayed

Abstract

Keywords

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