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Vol. 26 No. 3 (2014): Vol 26 Issue 3

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Physiological Activity of Chinese Lichen (Gyrophora esculenta) Component, Methyl 2,4-Dihydroxy-6-methylbenzoate and the Related Compounds

https://doi.org/10.14233/ajchem.2014.15485
Shuhsien Wu
Graduate School of Systems Engineering, Major of Systems Engineering, Kinki University, Takayaumenobe 1, Higashihiroshima, Hiroshima 739-2116, Japan
Zhendong Zhao
Institute of Chemical Industry of Forest Products, CAF; National Engineering Lab. for Biomass Chemical Utilization; Key and Open Lab. on Forest Chemical Engineering, SFA; Key Lab. of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China. No. 16, Suojin Wucun, Nanjing 210042, P.R. China
Yoshiharu Okada
Department of Biotechnology and Chemistry, Faculty of Engineering, Kinki University, Takayaumenobe 1, Higashihiroshima, Hiroshima, 739-2116, Japan
Yoshiyuki Watanabe
Department of Biotechnology and Chemistry, Faculty of Engineering, Kinki University, Takayaumenobe 1, Higashihiroshima, Hiroshima, 739-2116, Japan
Toshiyuki Takahata
Graduate School of Systems Engineering, Major of Systems Engineering, Kinki University, Takayaumenobe 1, Higashihiroshima, Hiroshima 739-2116, Japan
Toshio Inoue
Department of Pharmaceutical Health Care and Life Sciences, Nihon Pharmaceutical University; Ina-machi 10281, Kida-Adachi, Saitama, 362-0806, Japan
Eiji Otsubo
Research Scientist, Research Scientist, Mitsubishi Tanabe Parma Inc, Kisarazu, Chiba, Japan
Jing Wang
Institute of Chemical Industry of Forest Products, CAF; National Engineering Lab. for Biomass Chemical Utilization; Key and Open Lab. on Forest Chemical Engineering, SFA; Key Lab. of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China. No. 16, Suojin Wucun, Nanjing 210042, P.R. China
Yanju Lu
Institute of Chemical Industry of Forest Products, CAF; National Engineering Lab. for Biomass Chemical Utilization; Key and Open Lab. on Forest Chemical Engineering, SFA; Key Lab. of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China. No. 16, Suojin Wucun, Nanjing 210042, P.R. China
Masato Nomura
Department of Biotechnology and Chemistry, Faculty of Engineering, Kinki University, Takayaumenobe 1, Higashihiroshima, Hiroshima, 739-2116, Japan

Corresponding Author(s) : Zhendong Zhao

zdzhao@189.cn

Asian Journal of Chemistry, Vol. 26 No. 3 (2014): Vol 26 Issue 3

Abstract

It was confirmed that there was a higher expression of antioxidant potential in methyl 2,4-dihydroxy-6-methylbenzoate (orsellinic acid methyl ester) (2), which was isolated from methanol extract oil of Chinese lichen Gyrophora esculenta rather than from commercialized ascorbic acid. Taking this into account, 4 types of compounds-(4-7) which are known to be related to compound (2)-have been synthesized by using 2,4-dihydroxy benzoic acid (3) as starting material. After that, some physiological activity tests on these compounds have been conducted in the following aspects: antioxidant potential, cytotoxicity, cytokine suppressant effect and histamine liberation inhibition and the effects have been evaluated, respectively. The result shows that (2) and methyl 2,4-dihydroxybenzoate (4) showed high radical expression in both antioxidant potential and histamine liberation inhibition. It was also found that none of these compounds expresses cytotoxicity.

Keywords

Chinese lichen Gyrophora esculenta Methyl 2 4-dihydroxy-6-methylbenzoate Cytokine Histamine Antioxidant
Wu, S., Zhao, Z., Okada, Y., Watanabe, Y., Takahata, T., Inoue, T., … Nomura, M. (2014). Physiological Activity of Chinese Lichen (Gyrophora esculenta) Component, Methyl 2,4-Dihydroxy-6-methylbenzoate and the Related Compounds. Asian Journal of Chemistry, 26(3), 702–708. https://doi.org/10.14233/ajchem.2014.15485
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