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New Chalcone from Garcinia oligantha and Its Cytotoxicity
Asian Journal of Chemistry,
Vol. 26 No. 2 (2014): Vol 26 Issue 2
Abstract
A new chalcone, (5,6-dimethoxybenzofuran-2-yl)(4-hydroxyphenyl)methanone was isolated from the stems of Garcinia oligantha. Its structure was elucidated by spectroscopic methods, including extensive 1D and 2D NMR. The new chalcone was tested for its cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3 and MCF7) and it showed modest cytotoxicity against A549 and MCF7 cell with IC50 values of 6.2 and 4.8 μM.
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- D. Obolskiy, I. Pischel, N. Siriwatanametanon and M. Heinrich, Phytother. Res., 23, 1047 (2009); doi:10.1002/ptr.2730.
- X.M. Gao, T. Yu, F. Lai, Y. Zhou, X. Liu, C.F. Qiao, J.Z. Song, S.L. Chen, K.Q. Luo and H.X. Xu, Bioorg. Med. Chem., 18, 4957 (2010); doi:10.1016/j.bmc.2010.06.014.
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- X. Liu, T. Yu, X.M. Gao, Y. Zhou, C.F. Qiao, Y. Peng, S.L. Chen, K.Q. Luo and H.X. Xu, J. Nat. Prod., 73, 1355 (2010); doi:10.1021/np100156w.
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- Y. Yang, T. Zhang, L. Xiao, L.X. Yang and R.Y. Chen, Fitoterapia, 81, 614 (2010); doi:10.1016/j.fitote.2010.03.005.
- Y. Zhang, Q. Hu, X. Gao, L. Yang, L. Shu and Y. Shen, Heterocycles, 85, 1925 (2012); doi:10.3987/COM-12-12505.
- E. Tripoli, M.L. Guardia, S. Giammanco, D.D. Majo and M. Giammanco, Food Chem., 104, 466 (2007); doi:10.1016/j.foodchem.2006.11.054.
- H. Seibert, E. Maser, K. Schweda, S. Seibert and M. Gülden, Food Chem. Toxicol., 49, 2398 (2011); doi:10.1016/j.fct.2011.06.055.
- J.X. Chen, H.Q. Leng, Y.X. Duan, W. Zhao, G.Y. Yang, Y.D. Guo, Y.K. Chen and Q.F. Hu, Phytochem. Lett., 6, 144 (2013); doi:10.1016/j.phytol.2012.12.001.
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References
D. Obolskiy, I. Pischel, N. Siriwatanametanon and M. Heinrich, Phytother. Res., 23, 1047 (2009); doi:10.1002/ptr.2730.
X.M. Gao, T. Yu, F. Lai, Y. Zhou, X. Liu, C.F. Qiao, J.Z. Song, S.L. Chen, K.Q. Luo and H.X. Xu, Bioorg. Med. Chem., 18, 4957 (2010); doi:10.1016/j.bmc.2010.06.014.
X.-M. Gao, T. Yu, F.S.F. Lai, J.-X. Pu, C.-F. Qiao, Y. Zhou, X. Liu, J.-Z. Song, K.Q. Luo and H.-X. Xu, Tetrahedron Lett., 51, 2442 (2010); doi:10.1016/j.tetlet.2010.02.147.
X. Liu, T. Yu, X.M. Gao, Y. Zhou, C.F. Qiao, Y. Peng, S.L. Chen, K.Q. Luo and H.X. Xu, J. Nat. Prod., 73, 1355 (2010); doi:10.1021/np100156w.
X.M. Gao, T. Yu, M.Z. Cui, J.X. Pu, X. Du, Q.B. Han, Q.F. Hu, T.C. Liu, K.Q. Luo and H.X. Xu, Bioorg. Med. Chem. Lett., 22, 2350 (2012); doi: 10.1016/j.bmcl.2012.01.068.
Y. Yang, T. Zhang, L. Xiao, L.X. Yang and R.Y. Chen, Fitoterapia, 81, 614 (2010); doi:10.1016/j.fitote.2010.03.005.
Y. Zhang, Q. Hu, X. Gao, L. Yang, L. Shu and Y. Shen, Heterocycles, 85, 1925 (2012); doi:10.3987/COM-12-12505.
E. Tripoli, M.L. Guardia, S. Giammanco, D.D. Majo and M. Giammanco, Food Chem., 104, 466 (2007); doi:10.1016/j.foodchem.2006.11.054.
H. Seibert, E. Maser, K. Schweda, S. Seibert and M. Gülden, Food Chem. Toxicol., 49, 2398 (2011); doi:10.1016/j.fct.2011.06.055.
J.X. Chen, H.Q. Leng, Y.X. Duan, W. Zhao, G.Y. Yang, Y.D. Guo, Y.K. Chen and Q.F. Hu, Phytochem. Lett., 6, 144 (2013); doi:10.1016/j.phytol.2012.12.001.
T. Mosmann, J. Immunol. Methods, 65, 55 (1983); doi:10.1016/0022-1759(83)90303-4.