Ion Pair Colorimetric Estimation of Dronedrone HCl in Solid Dosages Using Methyl Orange

Mani Ganesh1; Pushparaj Hemalatha1; Mei Mei Peng1; Rajangam Vinodh1; Kalaimani Sakthimanig; Hyun Tae Jang1

doi:10.14233/ajchem.2014.16407

Issue

Vol. 26 No. 2 (2014): Vol 26 Issue 2

Issue Published : January 15, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

Ion Pair Colorimetric Estimation of Dronedrone HCl in Solid Dosages Using Methyl Orange

https://doi.org/10.14233/ajchem.2014.16407

Mani Ganesh1

1Department of Chemical Engineering, Hanseo University, 360 Daegok-ri, Haemi-myun, Seosan-si 356 706, Chungcheongnam-do, Republic of Korea 2Alkem Lab Ltd., C-17/7, MIDC Industrial Area, Taloja-410208, Raigad District, India *Corresponding author: Tel: +82 41 6601423; E-mail: htjang@hanseo.ac.kr

Pushparaj Hemalatha1

Mei Mei Peng1

Rajangam Vinodh1

Kalaimani Sakthimanig

Hyun Tae Jang1

Asian Journal of Chemistry, Vol. 26 No. 2 (2014): Vol 26 Issue 2
Article Published : January 16, 2014

Abstract

New ion pair colorimetric method has been developed for the estimation of dronedrone in bulk and in tablet formulation using methyl orange dye as an ion paring complexant using pH 4 buffer. The developed method has been validated for its sensitivity and specificity. The intensity of ion pair complex of dronedrone and methyl orange found linear over the range of 2-20 μg mL^-1 with a correlation coefficient of 0.9958. The inter and intraday precision, accuracy, stability, LOD, LOQ, placebo interference, robustness and ruggedness were evaluated during validation. The % RSD found for the recovery of the method resulted with low value of about 0.72-0.99; and with good precision. From the results obtained the developed method was found suitable and comparable in terms of estimating dronedrone in formulation with that of existing methods.

Keywords

Dronedrone Methyl orange Ion association Spectrophotometric.

Ganesh1, M., Hemalatha1, P., Mei Peng1, M., Vinodh1, R., Sakthimanig, K., & Tae Jang1, H. (2014). Ion Pair Colorimetric Estimation of Dronedrone HCl in Solid Dosages Using Methyl Orange. Asian Journal of Chemistry, 26(2), 621–624. https://doi.org/10.14233/ajchem.2014.16407

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http://www.rxlist.com/multaq-drug.htm (Accessed on: 23/09/2013).

W. Rosamond, K. Flegal, K. Furie, A. Go, K. Greenlund, N. Haase, S.M. Hailpern, M. Ho, V. Howard, B. Kissela, S. Kittner, D. Lloyd-Jones, M. McDermott, J. Meigs, C. Moy, G. Nichol, C. O’Donnell, V. Roger, P. Sorlie, J. Steinberger, T. Thom, M. Wilson and Y. Hong, Circulation, 117, e25 (2008); doi:10.1161/CIRCULATIONAHA.107.187998.

M.J. Tafreshi and J. Rowles, J. Cardiovasc. Pharmacol. Ther., 12, 15 (2007); doi:10.1177/1074248406299069.

Y. Watanabe and J. Kimura, Naunyn Schmiedebergs Arch. Pharmacol., 377, 371 (2008); doi:10.1007/s00210-008-0270-2.

R.L. McNamara, L.J. Tamariz and J.B. Segal, Ann. Intern. Med., 139, 1018 (2003); doi:10.7326/0003-4819-139-12-200312160-00012.

N. Wadhani, J.S. Sarma, B.N. Singh, D. Radzik and C. Gaud, J. Cardiovasc. Pharmacol. Ther., 11, 184 (2006); doi:10.1177/1074248406290678.

P. Touboul, J. Brugada, A. Capucci, H.J. Crijns, N. Edvardsson and S.H. Hohnloser, Eur. Heart J., 24, 1481 (2003); doi:10.1016/S0195-668X(03)00321-X.

K. Pravalika, M. Induri, M. Sudhakar and A. Fathima, World J. Pharm. Sci., 1, 15 (2013).

A. Patel and J. Akhtar, J. Chem. Pharm. Res., 4, 2173 (2012).

V.K. Ahirrao, C.S. Patil, S.R. Bembalkar, M.V. Katariya, V.S. Sonnekar, R.P. Marathe, R.B. Nawale and R.P. Pawar, J. Chil. Chem. Soc., 57, 1272 (2012); doi:10.4067/S0717-97072012000300016.

B. Dabhi, Y. Jadeja, M. Patel, H. Jebaliya, D. Karia and A. Shah, Sci. Pharm., 81, 115 (2013); doi:10.3797/scipharm.1209-15.

Ch. Rajyalakshmi, T. Benjamin and C. Rambabu, Der Pharma Chemica, 5, 189 (2013).

S. Molleti, V. Rao and K.N. Jayaveera, Der Pharma Chemica, 5, 334 (2013).

K.K. Bhatt, E.M. Patelia and I. Amin, J. Anal. Bioanal. Techniques, 4, 1 (2013).

B. Dabhi, H. Jebaliya, M. Patel, Y. Jadeja, D. Karia and A. Shah, Int. J. Pharm. Sci. Rev. Res., 17, 48 (2012).

C. Xie, S. Yang, D. Zhong, X. Dai and X. Chen, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 879, 3071 (2011); doi:10.1016/j.jchromb.2011.09.004.

ICH, Validation of analytical procedures: Text and methodology Q2 (R1), International Conference on Harmonization, Geneva, November (1996).

The United States Pharmacopeia, The National Formulary 19, US Pharmacopeial Convention Inc., Rockville, MD (2000).

19. P. Job, Advanced Physico Chemical Experiments, (Eds: Oliner, Boyd). Edinburgh, UK, p. 54 (1964).

Issue

Vol. 26 No. 2 (2014): Vol 26 Issue 2

Ion Pair Colorimetric Estimation of Dronedrone HCl in Solid Dosages Using Methyl Orange

Abstract

Keywords

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