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An Efficient Method on Nitration of Eugenol Using NH4NO3 and KHSO4
Corresponding Author(s) : I.M. Sudarma
Asian Journal of Chemistry,
Vol. 26 No. 1 (2014): Vol 26 Issue 1
Abstract
The main objective of this research was to find new method for the synthesis of nitro-eugenol. Nitro-eugenol is of considerable importance in the production of other fine chemicals such as amino-eugenol for further chemical synthesis and has also been reported to possess antibacterial, antioxidant and anticancer properties. In an attempt to synthesize nitro-eugenol in high yield, some different nitration methods of eugenol have been applied. An efficient method using NH4NO3 in the presence of KHSO4 as a catalyst has been found to give nitro-eugenol in good yield.
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- S.A. Burt and R.D. Reinders, Lett. Appl. Microbiol., 36, 162 (2003); doi:10.1046/j.1472-765X.2003.01285.x.
- S.I. Kim, J.H. Yi, J.- Tak and Y.-J. Ahn, Vet. Parasitol., 120, 297 (2004); doi:10.1016/j.vetpar.2003.12.016.
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- http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-clove.html.
- M.A. Zolfigol, E. Ghaemi and E. Madrakian, Molecules, 6, 614 (2001); doi:10.3390/60700614.
- R.O.C .Norman, R. Taylor, Electrophilic Substitution in Benzenoid Compounds, Elsevier, Amsterdan, 301 (1965).
- 8 H. Carrasco A, L. Espinoza C, V. Cardile, C. Gallardo, W. Cardona, L. Lombardo, K. Catalán M, M. Cuellar F and A. Russo, J. Braz. Chem. Soc., 19, 543 (2008); doi:10.1590/S0103-50532008000300024.
- I M. Sudarma, M. Ulfa and Sarkono, Indo. J. Chem., 9, 84 (2009).
- I M. Sudarma and sM. Ulfa, Indo. J. Chem., 9, 267 (2009).
- I.M. Sudarma, 2010, Proceeding International Conference on Medicinal Plant, WMCU, Surabaya, vol. 1, 1 – 6.
- J. Mannoppo, 2008, http://molucasablog.blogspot.com/2010/06/isolasi-eugenol- dari-bunga-cengkeh-dan.html.
- B. Baghernejad, M.M. Heravi, H.A. Oskooie and Y.S. Beheshtiha, J. Sci., 22, 169 (2009).
References
S.A. Burt and R.D. Reinders, Lett. Appl. Microbiol., 36, 162 (2003); doi:10.1046/j.1472-765X.2003.01285.x.
S.I. Kim, J.H. Yi, J.- Tak and Y.-J. Ahn, Vet. Parasitol., 120, 297 (2004); doi:10.1016/j.vetpar.2003.12.016.
Y. Li, C. Xu, Q. Zhang, J.Y. Liu and R.X. Tan, J. Ethnopharmacol, 98, 329 (2005); doi: 10.1016/j.jep.2005.01.020.
M. Pisano, G. Pagnan, M. Loi, M.E. Mura, M.G. Tilocca, G. Palmieri, D. Fabbri, M.A. Dettori, G. Delogu, M. Ponzoni and C. Rozzo, Mol. Cancer, 6, 8 (2007); doi:10.1186/1476-4598-6-8.
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-clove.html.
M.A. Zolfigol, E. Ghaemi and E. Madrakian, Molecules, 6, 614 (2001); doi:10.3390/60700614.
R.O.C .Norman, R. Taylor, Electrophilic Substitution in Benzenoid Compounds, Elsevier, Amsterdan, 301 (1965).
8 H. Carrasco A, L. Espinoza C, V. Cardile, C. Gallardo, W. Cardona, L. Lombardo, K. Catalán M, M. Cuellar F and A. Russo, J. Braz. Chem. Soc., 19, 543 (2008); doi:10.1590/S0103-50532008000300024.
I M. Sudarma, M. Ulfa and Sarkono, Indo. J. Chem., 9, 84 (2009).
I M. Sudarma and sM. Ulfa, Indo. J. Chem., 9, 267 (2009).
I.M. Sudarma, 2010, Proceeding International Conference on Medicinal Plant, WMCU, Surabaya, vol. 1, 1 – 6.
J. Mannoppo, 2008, http://molucasablog.blogspot.com/2010/06/isolasi-eugenol- dari-bunga-cengkeh-dan.html.
B. Baghernejad, M.M. Heravi, H.A. Oskooie and Y.S. Beheshtiha, J. Sci., 22, 169 (2009).