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Vol. 26 No. 24 (2014)

Copyright (c) 2014 Azza A. Hussain1, Mohamed M. Abdulla2, Abd El-Galil E. Amr3, Mohamed A. Al-Omar3, Ahmed F.A. Shalaby1

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Anti-Inflammatory Activities of Some New Substituted Benzocarboxamide Pyrimidine Derivatives Using N-(4-Acetylphenyl)-5-chloro-2-methoxybenzamide as Starting Material

https://doi.org/10.14233/ajchem.2014.18253
Azza A. Hussain1
1Chemistry Department, Faculty of Science, Cairo University, Giza Egypt 2Research Unit, Saco Pharm. Co., 6th October City 11632, Egypt 3Pharmaceutical Chemistry Department, Drug Exploration and Development Chair, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 4Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, Egypt *Corresponding author: E-mail: hussainazza2014@yahoo.com
Mohamed M. Abdulla2
1Chemistry Department, Faculty of Science, Cairo University, Giza Egypt 2Research Unit, Saco Pharm. Co., 6th October City 11632, Egypt 3Pharmaceutical Chemistry Department, Drug Exploration and Development Chair, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 4Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, Egypt *Corresponding author: E-mail: hussainazza2014@yahoo.com
Abd El-Galil E. Amr3
1Chemistry Department, Faculty of Science, Cairo University, Giza Egypt 2Research Unit, Saco Pharm. Co., 6th October City 11632, Egypt 3Pharmaceutical Chemistry Department, Drug Exploration and Development Chair, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 4Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, Egypt *Corresponding author: E-mail: hussainazza2014@yahoo.com
Mohamed A. Al-Omar3
1Chemistry Department, Faculty of Science, Cairo University, Giza Egypt 2Research Unit, Saco Pharm. Co., 6th October City 11632, Egypt 3Pharmaceutical Chemistry Department, Drug Exploration and Development Chair, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 4Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, Egypt *Corresponding author: E-mail: hussainazza2014@yahoo.com
Ahmed F.A. Shalaby1
1Chemistry Department, Faculty of Science, Cairo University, Giza Egypt 2Research Unit, Saco Pharm. Co., 6th October City 11632, Egypt 3Pharmaceutical Chemistry Department, Drug Exploration and Development Chair, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 4Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, Egypt *Corresponding author: E-mail: hussainazza2014@yahoo.com

Corresponding Author(s) : Azza A. Hussain1

Asian Journal of Chemistry, Vol. 26 No. 24 (2014)

Abstract

A series of substituted pyrimidine derivatives (2-6) were prepared from corresponding chalcones, which were prepared from N-(4-acetylphenyl)-5-chloro-2-methoxybenzamide as starting material. The structure assignments of the newly synthesized compounds are based on chemical and spectroscopic evidence. The pharmacological screening showed that many of these compounds have less toxicity and good anti-inflammatory activities.

Keywords

5-Chloroanisic acid Cinnamoyl derivatives Pyrimidines Antiinflammatory activities.
A. Hussain1, A., M. Abdulla2, M., El-Galil E. Amr3, A., A. Al-Omar3, M., & F.A. Shalaby1, A. (2014). Synthesis and Anti-Inflammatory Activities of Some New Substituted Benzocarboxamide Pyrimidine Derivatives Using N-(4-Acetylphenyl)-5-chloro-2-methoxybenzamide as Starting Material. Asian Journal of Chemistry, 26(24), 8514–8520. https://doi.org/10.14233/ajchem.2014.18253
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