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Vol. 26 No. 24 (2014)

Copyright (c) 2014 Raed Ghanem

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Kinetics Study of the Chemical Oxidation of Pindolol by Peroxodiphosphate

https://doi.org/10.14233/ajchem.2014.18220
Raed Ghanem
Department of Chemistry. University of Al al-Bayt, P.O. Box 130040, Mafraq 25113, Jordan Corresponding author: Tel: +962 795150054; E-mail: readsa@yahoo.com, raedag@aabu.edu.jo

Corresponding Author(s) : Raed Ghanem

Asian Journal of Chemistry, Vol. 26 No. 24 (2014)

Abstract

In order to analyze the selectivity of the oxidizing agent on the chemical oxidation of pindolol in methanol/acidic media, the reaction of pindolol by peroxodiphosphate [PDP] in acidic media was studied. It was found that the reaction mechanism is comparable with other peroxides, however, reaction products are different depending on the acidity condition, at low acid concentration, oxipindolol is formed through acid catalyzed transformation of the indonlonic intermediate while at high acid concentration, the intermediate can react through competing parallel reaction to produce three products (oxipindolol, dioxipindolol and indigo form of pindolol) for the 1-PDP reaction. It is also found that, under present experimental conditions, neutral H4P2O8 is the active species involved in the oxidation process. Comparison of kinetics behaviour of the 1-PDP reaction with other peroxides were also investigated and we conclude that H4P2O8 is more reactive than H2S2O8 while HS2O8– is better electrophilic compared to the H3P2O8–.

Keywords

Pindolol Kinetic Polar mechanism Peroxodiphosphate.
Ghanem, R. (2014). Kinetics Study of the Chemical Oxidation of Pindolol by Peroxodiphosphate. Asian Journal of Chemistry, 26(24), 8488–8496. https://doi.org/10.14233/ajchem.2014.18220
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