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Vol. 26 No. 24 (2014)

Copyright (c) 2014 Rendong Ji1, Zhimin Zhao1, Xingyue Zhu1, Menglan Chen1, Xiaoyan Wang1

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Spectroscopic Studies on Interaction Between Enalapril Maleate and Bovine Serum Albumin

https://doi.org/10.14233/ajchem.2014.17844
Rendong Ji1
1Nanjing University of Aeronautics and Astronautics, Nanjing 210016, P.R. China 2Huaiyin Institute of Technology, Huaian 223003, P.R. China *Corresponding author: Tel/Fax: +86 25 84892011; E-mail: nuaazhzhm@126.com; jrdgxy@163.com
Zhimin Zhao1
1Nanjing University of Aeronautics and Astronautics, Nanjing 210016, P.R. China 2Huaiyin Institute of Technology, Huaian 223003, P.R. China *Corresponding author: Tel/Fax: +86 25 84892011; E-mail: nuaazhzhm@126.com; jrdgxy@163.com
Xingyue Zhu1
1Nanjing University of Aeronautics and Astronautics, Nanjing 210016, P.R. China 2Huaiyin Institute of Technology, Huaian 223003, P.R. China *Corresponding author: Tel/Fax: +86 25 84892011; E-mail: nuaazhzhm@126.com; jrdgxy@163.com
Menglan Chen1
1Nanjing University of Aeronautics and Astronautics, Nanjing 210016, P.R. China 2Huaiyin Institute of Technology, Huaian 223003, P.R. China *Corresponding author: Tel/Fax: +86 25 84892011; E-mail: nuaazhzhm@126.com; jrdgxy@163.com
Xiaoyan Wang1
1Nanjing University of Aeronautics and Astronautics, Nanjing 210016, P.R. China 2Huaiyin Institute of Technology, Huaian 223003, P.R. China *Corresponding author: Tel/Fax: +86 25 84892011; E-mail: nuaazhzhm@126.com; jrdgxy@163.com

Corresponding Author(s) : Rendong Ji1

Asian Journal of Chemistry, Vol. 26 No. 24 (2014)

Abstract

The interaction between enalapril maleate and bovine serum albumin was investigated by fluorescence and absorption spectroscopy under simulative physiological conditions. It was revealed that the quenching mechanism of bovine serum albumin by enalapril maleate is static quenching mechanism. The binding sites number and binding constant were obtained at different temperature. The thermodynamic parameters were abtained according to van’t Hoff equation and the result indicates that the interaction between enalapril maleate and bovine serum albumin is driven mainly by electrostatic forces. The distance between enalapril maleate and the protein was calculated to be about 3.78 nm according to the theory of Föster energy transfer.

Keywords

Bovine serum albumin Enalapril maleate Fluorescence spectroscopy Binding constant.
Ji1, R., Zhao1, Z., Zhu1, X., Chen1, M., & Wang1, X. (2014). Spectroscopic Studies on Interaction Between Enalapril Maleate and Bovine Serum Albumin. Asian Journal of Chemistry, 26(24), 8423–8426. https://doi.org/10.14233/ajchem.2014.17844
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