Issue

Vol. 26 No. 23 (2014)

Copyright (c) 2014 B. Pejin1, T. Kartali2, B. Stanimirovic3, M. Karaman2

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Phytol May Inspire New Medicinal Foods for the Treatment of Heart Disease

https://doi.org/10.14233/ajchem.2014.18571
B. Pejin1
1University of Belgrade, Institute for Multidisciplinary Research - IMSI, Department of Life Sciences, Kneza Viseslava 1, 11030 Belgrade, Serbia 2University of Novi Sad, Faculty of Sciences, Department of Biology and Ecology, Trg Dositeja Obradovica 2, 21000 Novi Sad, Serbia 3Institute MOL Ltd, Nikole Tesle 15, 22300 Stara Pazova, Serbia *Corresponding author: E-mail: brspjn@gmail.com, boris.pejin@imsi.rs
T. Kartali2
1University of Belgrade, Institute for Multidisciplinary Research - IMSI, Department of Life Sciences, Kneza Viseslava 1, 11030 Belgrade, Serbia 2University of Novi Sad, Faculty of Sciences, Department of Biology and Ecology, Trg Dositeja Obradovica 2, 21000 Novi Sad, Serbia 3Institute MOL Ltd, Nikole Tesle 15, 22300 Stara Pazova, Serbia *Corresponding author: E-mail: brspjn@gmail.com, boris.pejin@imsi.rs
B. Stanimirovic3
1University of Belgrade, Institute for Multidisciplinary Research - IMSI, Department of Life Sciences, Kneza Viseslava 1, 11030 Belgrade, Serbia 2University of Novi Sad, Faculty of Sciences, Department of Biology and Ecology, Trg Dositeja Obradovica 2, 21000 Novi Sad, Serbia 3Institute MOL Ltd, Nikole Tesle 15, 22300 Stara Pazova, Serbia *Corresponding author: E-mail: brspjn@gmail.com, boris.pejin@imsi.rs
M. Karaman2
1University of Belgrade, Institute for Multidisciplinary Research - IMSI, Department of Life Sciences, Kneza Viseslava 1, 11030 Belgrade, Serbia 2University of Novi Sad, Faculty of Sciences, Department of Biology and Ecology, Trg Dositeja Obradovica 2, 21000 Novi Sad, Serbia 3Institute MOL Ltd, Nikole Tesle 15, 22300 Stara Pazova, Serbia *Corresponding author: E-mail: brspjn@gmail.com, boris.pejin@imsi.rs

Corresponding Author(s) : B. Pejin1

Asian Journal of Chemistry, Vol. 26 No. 23 (2014)

Abstract

This study aimed to investigate in vitro antibacterial activity of phytol against the selected Gram positive bacteria (Clostridium sporogenes, Enterococcus faecalis and Sarcina lutea) involved in the pathogenesis of infective endocarditis. The examined natural product has proved to be active against all the tested bacteria, but to a varying degree. Indeed, phytol inhibited E. faecalis growth (MIC 1.56 ± 0.04 μg/mL) more effectively than gentamycin and ampicillin (MIC 5.00 ± 0.06 and 16.00 ± 0.03 μg/mL, respectively). Both its freely presence in nutrition and easy availability support the development of a new phytol based medicinal foods targeting heart disease.

Keywords

Diterpene alcohol Antibacterial activity Enterococcus faecalis Infective endocarditis.
Pejin1, B., Kartali2, T., Stanimirovic3, B., & Karaman2, M. (2014). Phytol May Inspire New Medicinal Foods for the Treatment of Heart Disease. Asian Journal of Chemistry, 26(23), 8261–8262. https://doi.org/10.14233/ajchem.2014.18571
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. E.S.J. Harris and B. Yang, Econ. Bot., 63, 190 (2009).
  2. T. Koponen, Ann. Bot. Fenn., 3, 399 (1966).
  3. A.J.E. Smith, The Moss Flora of Britain and Ireland, Cambridge University Press, Cambridge, pp. 1012 (2004).
  4. K. Dierssen, in ed.: J. Cramer, Distribution, Ecological Amplitude and Phyto-sociological Characterization of European Bryophytes, ed., Bryo-phytorum Bibliotheca, Vol. 56, Berlin, p. 289 (2001).
  5. B. Pejin, Lj. Vujisic, M. Sabovljevic, V. Tesevic and V. Vajs, Cryptogamie Bryol., 32, 113 (2011).
  6. T. Özdemir, N. Yayli, T.B. Cansu, C. Volga and N. Yayli, Asian J. Chem., 21, 5505 (2009).
  7. P. Olofsson, M. Hultqvist and R. Holmdahl, United States Patent Appl-ication Publication, Appl. No. 12/921,169 (2011).
  8. M.M. Elmazar, H.S. El-Abhar, S.M.F. Chaalan and N.A. Farag, PLoS ONE, 8, e45638 (2013).
  9. D. Kumar, J.J. Cawley, J.M. Irizarry-Alvarado, A. Alvarez and S. Alvarez, Transpl. Infect. Dis., 9, 336 (2007).
  10. R.S. Mitchell, V. Kumar, S.L. Robbins, A.K. Abbas and N. Fausto, Robbins Basic Pathology, Saunders/Elsevier, Philadelphia, pp. 960 (2007).
  11. J.M. Miro, J.M. Pericas and A. del Rio, Circulation, 127, 1763 (2013).
  12. L. Clontz, Microbial Limit and Bioburden Tests: Validation Approaches and Global Requirements, CRC Press, Boca Raton, pp. 280 (2009).
  13. G. Miltiadous and M. Elisaf, J. Med. Case Reports, 5, 251 (2011).
  14. M. Karaman, N. Mimica-Dukic, P. Knezevic, Z. Svircev and M. Matavuly, Int. J. Med. Mushrooms, 11, 269 (2009).
  15. M.S. Rajab, C.L. Cantrell, S.G. Franzblau and N.H. Fischer, Planta Med., 64, 2 (1998).
  16. B. Pejin, A. Savic, M. Sokovic, J. Glamoclija, A. Ciric, M. Nikolic, K. Radotic and M. Mojovic, Nat. Prod. Res., 28, 372 (2014).
  17. J.-F. Rontani and J.K. Volkman, Org. Geochem., 34, 1 (2003).
Read More
Author biographies is not available.
Download
Statistic
Read Counter : 0