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Vol. 26 No. 23 (2014)

Copyright (c) 2014 A. Arrahman1, H. Suryadi2, A. Yanuar1

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Microwave Assisted Synthesis of Pyridin-1-ium Salt of 6-Nitroquinazolin-4-one and its 6-Amino Analog under Ultrasonic Irradiation

https://doi.org/10.14233/ajchem.2014.16697
A. Arrahman1
1Pharmaceutical Chemistry Laboratory, Faculty of Pharmacy, University of Indonesia, Depok 16424, West Java, Indonesia 2Microbiology Laboratory, Faculty of Pharmacy, University of Indonesia, Depok 16424, West Java, Indonesia *Corresponding author: Fax: +62 21 7863433; Tel: +62 21 7270031; E-mail: hayun.ms@ui.ac.id
H. Suryadi2
1Pharmaceutical Chemistry Laboratory, Faculty of Pharmacy, University of Indonesia, Depok 16424, West Java, Indonesia 2Microbiology Laboratory, Faculty of Pharmacy, University of Indonesia, Depok 16424, West Java, Indonesia *Corresponding author: Fax: +62 21 7863433; Tel: +62 21 7270031; E-mail: hayun.ms@ui.ac.id
A. Yanuar1
1Pharmaceutical Chemistry Laboratory, Faculty of Pharmacy, University of Indonesia, Depok 16424, West Java, Indonesia 2Microbiology Laboratory, Faculty of Pharmacy, University of Indonesia, Depok 16424, West Java, Indonesia *Corresponding author: Fax: +62 21 7863433; Tel: +62 21 7270031; E-mail: hayun.ms@ui.ac.id

Corresponding Author(s) : A. Arrahman1

Asian Journal of Chemistry, Vol. 26 No. 23 (2014)

Abstract

The new compounds of quinazolin-4-one derivative i.e., 2-methyl-6-nitroquinazolin-4-one substituted pyridin-1-ium salt at methyl group and its 6-amino analog have been synthesized. Microwave irradiation of solution of 2-bromomethyl-6-nitroquinazolin-4-one and pyridine in acetonitrile for 3 min afforded 1-[(6-nitroquinazolin-4-one-2-yl)methyl]pyridin-1-ium bromide; and nitro reduction of the product with iron in ethanol/acetic acid/water under ultrasonic irradiation afforded 1-[(6-aminoquinazolin-4-one-2-yl)methyl]pyridin-1-ium bromide. The structure of the synthesized compounds were confirmed on the basis of FT-IR, 1H NMR and 13C NMR data.

Keywords

Pyridinium salt Quinazolin-4-one 6-Nitroquinazolin-4-one 6-Aminoquinazolin-4-one Ultrasound Aqueous media Microwave.
Arrahman1, A., Suryadi2, H., & Yanuar1, A. (2014). Microwave Assisted Synthesis of Pyridin-1-ium Salt of 6-Nitroquinazolin-4-one and its 6-Amino Analog under Ultrasonic Irradiation. Asian Journal of Chemistry, 26(23), 7904–7906. https://doi.org/10.14233/ajchem.2014.16697
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