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Vol. 26 No. 23 (2014)

Copyright (c) 2014 Nagy M. Khalifa1, Ahmed M. Naglah1, Mohamed A. Al-Omar1, Abd El-Galil E. Amr1

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Synthesis and Screening of Some Novel Substituted Indoles Contained Fused Triazolo[1,5-a]pyridine and Thiazolo[3,2-a]pyridine Derivatives

https://doi.org/10.14233/ajchem.2014.17869
Nagy M. Khalifa1
1Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 2Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, Dokki 12622, Cairo, Egypt 3Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, Dokki 12622, Cairo, Egypt 4Applied Organic Chemistry Department, National Research Center, Cairo, Dokki, Egypt *Corresponding author: E-mail: nagykhalifa@hotmail.com
Ahmed M. Naglah1
1Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 2Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, Dokki 12622, Cairo, Egypt 3Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, Dokki 12622, Cairo, Egypt 4Applied Organic Chemistry Department, National Research Center, Cairo, Dokki, Egypt *Corresponding author: E-mail: nagykhalifa@hotmail.com
Mohamed A. Al-Omar1
1Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 2Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, Dokki 12622, Cairo, Egypt 3Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, Dokki 12622, Cairo, Egypt 4Applied Organic Chemistry Department, National Research Center, Cairo, Dokki, Egypt *Corresponding author: E-mail: nagykhalifa@hotmail.com
Abd El-Galil E. Amr1
1Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 2Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, Dokki 12622, Cairo, Egypt 3Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, Dokki 12622, Cairo, Egypt 4Applied Organic Chemistry Department, National Research Center, Cairo, Dokki, Egypt *Corresponding author: E-mail: nagykhalifa@hotmail.com

Corresponding Author(s) : Nagy M. Khalifa1

Asian Journal of Chemistry, Vol. 26 No. 23 (2014)

Abstract

A series of heterocyclic derivatives including 1H-pyrazol-4-carbonitrile (3), 1H pyrazol-5(4H)-one (4,5), 2-thioxopyrimidine-4,6-dione (6) 1,2,4-triazole-3(4H)-one (7), 1,6-diaminopyridine (9), triazolo[1,5-a]pyridin (10) and thiazolo[3,2-a]pyridine (11) moieties conjugated with 1-substituted indole moiety were synthesized on reaction with cyanoacetohydrazide, 3-amino-5-oxo-2-pyrazoline, thiobarbituric acid, thiosemicarbazide, malononitrile followed by cyanoacetohydrazide, different aromatic aldehydes and mercaptoacetic acid, respectively, by using 1-[2-(piperidin-1-yl)ethyl]-1H-indole-3-carbaldehyde (1) as starting material. The structures of all the newly synthesized products have been established on the basis of analytical and spectral data.The antimicrobial activity of some selected products was examined and some of them showed good activities.

Keywords

N-substituted indole derivatives Triazolo[1 5-a]pyridine Thiazolo[3 2-a]pyridine Antimicrobial activity.
M. Khalifa1, N., M. Naglah1, A., A. Al-Omar1, M., & El-Galil E. Amr1, A. (2014). Synthesis and Screening of Some Novel Substituted Indoles Contained Fused Triazolo[1,5-a]pyridine and Thiazolo[3,2-a]pyridine Derivatives. Asian Journal of Chemistry, 26(23), 8185–8190. https://doi.org/10.14233/ajchem.2014.17869
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