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Vol. 26 No. 23 (2014)

Copyright (c) 2014 Changyan Hu, Dongling Wang, Kunquan Chen, Xu Liu, Qichao Chen, Dequn Sun*

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Development and Validation of Process for Resolution of Praziquantel Amine for Preparation of Chiral Praziquantel

https://doi.org/10.14233/ajchem.2014.17661
Changyan Hu
Marine College, Shandong University, Weihai Wenhua West Road, No. 180, Weihai 264209, P.R. China *Corresponding author: E-mail: dequn.sun@sdu.edu.cn
Dongling Wang
Marine College, Shandong University, Weihai Wenhua West Road, No. 180, Weihai 264209, P.R. China *Corresponding author: E-mail: dequn.sun@sdu.edu.cn
Kunquan Chen
Marine College, Shandong University, Weihai Wenhua West Road, No. 180, Weihai 264209, P.R. China *Corresponding author: E-mail: dequn.sun@sdu.edu.cn
Xu Liu
Marine College, Shandong University, Weihai Wenhua West Road, No. 180, Weihai 264209, P.R. China *Corresponding author: E-mail: dequn.sun@sdu.edu.cn
Qichao Chen
Marine College, Shandong University, Weihai Wenhua West Road, No. 180, Weihai 264209, P.R. China *Corresponding author: E-mail: dequn.sun@sdu.edu.cn
Dequn Sun*
Marine College, Shandong University, Weihai Wenhua West Road, No. 180, Weihai 264209, P.R. China *Corresponding author: E-mail: dequn.sun@sdu.edu.cn

Corresponding Author(s) : Changyan Hu

Asian Journal of Chemistry, Vol. 26 No. 23 (2014)

Abstract

Investigation of the viability of scale up preparation for chiral praziquantel was included in WHO/TDR business plan. Resolution is the major strategy for preparation of single enantiomer. In this study, a stable and effective resolution approach toward the important intermediate praziquantel amine for preparation of chiral praziquantel was developed and the process was optimized to afford high ee value and good yield. The suitable HPLC method was validated for the determination of ee value of chiral praziquantel amine.

Keywords

Schistosomiasis Praziquantel Resolution Chiral praziquantel amine Chiral HPLC analysis Validation.
Hu, C., Wang, D., Chen, K., Liu, X., Chen, Q., & Sun*, D. (2014). Development and Validation of Process for Resolution of Praziquantel Amine for Preparation of Chiral Praziquantel. Asian Journal of Chemistry, 26(23), 8158–8162. https://doi.org/10.14233/ajchem.2014.17661
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