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Vol. 26 No. 23 (2014)

Copyright (c) 2014 A.A. Radwan1, T. Aboul-Fadl3, A. Al-Dhfyan4, W.M. Abdel-Mageeda6

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Characterization of bis-3,5-Disubstituted Thiadiazine-2-thione Derivatives as Anticancer Agents

https://doi.org/10.14233/ajchem.2014.17636
A.A. Radwan1
1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt 2Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 3Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt 4Stem Cell Therapy Program, King Faisal Specialized Hospital and Research Center, Riyadh 11211, Saudi Arabia 5Department of Pharmacology, King Saud University, Riyadh, Saudi Arabia 6Pharmacognosy Department, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box 2457, Saudi Arabia 7Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt *Corresponding author: Tel: +966 146 70562; E-mail: dhna_2001@hotmail.com
T. Aboul-Fadl3
1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt 2Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 3Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt 4Stem Cell Therapy Program, King Faisal Specialized Hospital and Research Center, Riyadh 11211, Saudi Arabia 5Department of Pharmacology, King Saud University, Riyadh, Saudi Arabia 6Pharmacognosy Department, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box 2457, Saudi Arabia 7Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt *Corresponding author: Tel: +966 146 70562; E-mail: dhna_2001@hotmail.com
A. Al-Dhfyan4
1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt 2Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 3Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt 4Stem Cell Therapy Program, King Faisal Specialized Hospital and Research Center, Riyadh 11211, Saudi Arabia 5Department of Pharmacology, King Saud University, Riyadh, Saudi Arabia 6Pharmacognosy Department, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box 2457, Saudi Arabia 7Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt *Corresponding author: Tel: +966 146 70562; E-mail: dhna_2001@hotmail.com
W.M. Abdel-Mageeda6
1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt 2Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 3Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt 4Stem Cell Therapy Program, King Faisal Specialized Hospital and Research Center, Riyadh 11211, Saudi Arabia 5Department of Pharmacology, King Saud University, Riyadh, Saudi Arabia 6Pharmacognosy Department, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box 2457, Saudi Arabia 7Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt *Corresponding author: Tel: +966 146 70562; E-mail: dhna_2001@hotmail.com

Corresponding Author(s) : A.A. Radwan1

Asian Journal of Chemistry, Vol. 26 No. 23 (2014)

Abstract

Selective cytotoxic effect toward tumor cells but not the normal tissues represent a major challenge in cancer drug discovery. Herein, we describe the synthesis and selective antitumor activity of some HHT. All the synthesized compounds showed a good antitumor activity against leukemia K562 cells. In regard to cytotoxicity in normal cells, compounds (1-11) showed no cytotoxic effect within 200 μM range, however compounds 12-16 showed non-selective cytotoxic effect.

Keywords

Synthesis Thiadiazine-2-thiones Anticancer.
Radwan1, A., Aboul-Fadl3, T., Al-Dhfyan4, A., & Abdel-Mageeda6, W. (2014). Synthesis and Characterization of bis-3,5-Disubstituted Thiadiazine-2-thione Derivatives as Anticancer Agents. Asian Journal of Chemistry, 26(23), 8145–8150. https://doi.org/10.14233/ajchem.2014.17636
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