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Vol. 26 No. 22 (2014): Vol 26 Issue 22

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Synthesis, Characterization of 3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline and Its Crystal Structure

https://doi.org/10.14233/ajchem.2014.16902
Jia-Ying Xu
College of Chemical and Biological Engineering, Yancheng Institute of Technology, Yancheng 224051, Jiangsu Province, P.R. China
Wei-Hua Cheng
Department of Light Chemical Engineering, Yancheng Institute of Industry Technology, Yancheng 224051, Jiangsu Province, P.R. China
Lan Wang
Department of Light Chemical Engineering, Yancheng Institute of Industry Technology, Yancheng 224051, Jiangsu Province, P.R. China
Jian-Guo Wu
Department of Light Chemical Engineering, Yancheng Institute of Industry Technology, Yancheng 224051, Jiangsu Province, P.R. China
Kai Wang
High Technology Research Institute of Nanjing University, Changzhou, 213162, Jiangsu Province, P.R. China

Corresponding Author(s) : Jia-Ying Xu

xujiaying-1984@163.com

Asian Journal of Chemistry, Vol. 26 No. 22 (2014): Vol 26 Issue 22

Abstract

3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline (I), an important intermediate to synthesize pitavastatin calcium. It was prepared from ethyl 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxylate via reduction by KBH4/ZnCl2 and then bromide by PBr3. The product was characterized by NMR and LC-MS. The crystal structure of compound I was investigated using X-ray diffraction and SHELXTL-97 software. The result indicated that compound I crystallized in the triclinic system, space group P-1 with a = 9.6150(19), b = 9.868 (2), c = 10.060(2) Å, V = 783.3 (4) Å3; Z 2.

Keywords

3-(Bromomethy)-2-cyclopropy-4-(4-fluorophenyl)quinolone Synthesis Characterization Crystal Structure
Xu, J.-Y., Cheng, W.-H., Wang, L., Wu, J.-G., & Wang, K. (2014). Synthesis, Characterization of 3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline and Its Crystal Structure. Asian Journal of Chemistry, 26(22), 7587–7590. https://doi.org/10.14233/ajchem.2014.16902
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