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Vol. 26 No. 21 (2014): Vol 26 Issue 21

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Synthesis and Antitumour Activity of Novel Colchicine C-10 Derivatives

https://doi.org/10.14233/ajchem.2014.16892
Li Hong Shen
Handan Key Laboratory of Organic Small Molecule Materials, Handan College, Handan 056005, P.R. China
Le Zhang
Handan Key Laboratory of Organic Small Molecule Materials, Handan College, Handan 056005, P.R. China
Hai Xian Wang
Handan Key Laboratory of Organic Small Molecule Materials, Handan College, Handan 056005, P.R. China
Xin Wang
Department of Chemistry, Handan College, Handan 056005, P.R. China
Gai Jiao Zhang
Department of chemistry, Handan college, Handan 056005, P.R. China

Corresponding Author(s) : Li Hong Shen

latishen@sohu.com

Asian Journal of Chemistry, Vol. 26 No. 21 (2014): Vol 26 Issue 21

Abstract

A series of new colchicine C-10 derivatives (2a-i, 3a-h) were synthesized by replacement of the 10-methoxy with NR2 and SCH3 in order to determine their cytotoxic activity. The compounds were synthesized in good yield and the structures of all newly synthesized compounds were established on the basis of their IR, 1H NMR and elemental analysis. The synthesized compounds were tested in vitro antitumor activity against four human cancer cell lines by MTT assay. It was found that many of the derivatives displayed significant activity, particularly, compound 2a and 2b showed more potent cytotoxic activities than colchicine.

Keywords

Colchicine Derivatives Cytotoxic activity
Hong Shen, L., Zhang, L., Xian Wang, H., Wang, X., & Jiao Zhang, G. (2014). Synthesis and Antitumour Activity of Novel Colchicine C-10 Derivatives. Asian Journal of Chemistry, 26(21), 7475–7476. https://doi.org/10.14233/ajchem.2014.16892
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