Synthesis and Antitumor Activities of Some 2-Oxo-quinoline-3-Schiff Base Derivatives

Yilin Fang; Xianghui Yi; Wen Qin; Ye Zhang; Yongzhi Liao

doi:10.14233/ajchem.2014.17186

Issue

Vol. 26 No. 21 (2014): Vol 26 Issue 21

Issue Published : September 30, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Antitumor Activities of Some 2-Oxo-quinoline-3-Schiff Base Derivatives

https://doi.org/10.14233/ajchem.2014.17186

Yilin Fang

College of Chemistry and Chemical Engineering, Hunan University, Hunan 410082, P.R. China

Xianghui Yi

Department of Chemistry, Guilin Normal College, Guangxi 541001, P.R. China

Wen Qin

Department of Chemistry, Guilin Normal College, Guangxi 541001, P.R. China

Ye Zhang

Department of Chemistry, Guilin Normal College, Guangxi 541001, P.R. China

Yongzhi Liao

Guangxi Academy of Fishery Sciences, Nanning 530021, P.R. China

Corresponding Author(s) : Ye Zhang

zhangye81@126.com

Asian Journal of Chemistry, Vol. 26 No. 21 (2014): Vol 26 Issue 21
Article Published : October 1, 2014

Abstract

A series of 2-oxo-quinoline-3-Schiff-base derivatives (4a₁-4n₂) have been designed and synthesized as new antitumor agents. in vitro Antitumor activities were evaluated against four cancer cell lines including MGC80-3, BEL-7404, A549 and NCI-H460. Compounds 4a₁, 4a₂, 4c₂, 4d₁, 4d₂ and 4l₂ exhibited better inhibition activities than commercial antitumor drug 5-fluorouracil (5-fluorouracil, IC₅₀ = 44 ± 0.54 μM) on NCI-H460, with IC₅₀ of 35.52 ± 0.86, 16.22 ± 0.71, 11.62 ± 0.52, 5.16 ± 0.37, 7.62 ± 0.46 and 7.66 ± 0.65 μM, respectively.

Keywords

2-Oxo-quinoline-3-Schiff-base derivatives Synthesis Antitumor activity

Fang, Y., Yi, X., Qin, W., Zhang, Y., & Liao, Y. (2014). Synthesis and Antitumor Activities of Some 2-Oxo-quinoline-3-Schiff Base Derivatives. Asian Journal of Chemistry, 26(21), 7449–7451. https://doi.org/10.14233/ajchem.2014.17186

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References

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References

B.N. Ames, M.K. Shigenaga and T.M. Hagen, Proc. Natl. Acad. Sci. USA, 90, 7915 (1993); doi:10.1073/pnas.90.17.7915.

Y.K. Tyagi, A. Kumar, H.G. Raj, P. Vohra, G. Gupta, R. Kumari, P. Kumar and R.K. Gupta, Eur. J. Med. Chem., 40, 413 (2005); doi:10.1016/j.ejmech.2004.09.002.

K. Iwasa, M. Moriyasu, Y. Tachibana, H. Kim, Y. Wataya, W. Wiegrebe, K.F. Bastow, L.M. Cosentino, M. Kozuka and K. Lee, Bioorg. Med. Chem., 9, 2871 (2001); doi:10.1016/S0968-0896(01)00154-7.

D.L. Minor, S.D. Wyrick, P.S. Charifson, V.J. Watts, D.E. Nichols and R.B. Mailman, J. Med. Chem., 37, 4317 (1994); doi:10.1021/jm00051a008.

R. Naito, Y. Yonetoku, Y. Okamoto, A. Toyoshima, K. Ikeda and M. Takeuchi, J. Med. Chem., 48, 6597 (2005); doi:10.1021/jm050099q.

J. Chen, X. Chen, M. Bois-Choussy and J. Zhu, J. Am. Chem. Soc., 128, 87 (2006); doi:10.1021/ja0571794.

J. DeRuiter, A.N. Brubaker, W.L. Whitmer and J.L. Stein, J. Med. Chem., 29, 2024 (1986); doi:10.1021/jm00160a038.

P. Hewawasam, W. Fan, J. Knipe, S.L. Moon, C.G. Boissard, V.K. Gribkoff and J.E. Starrett Jr, Bioorg. Med. Chem. Lett., 12, 1779 (2002); doi:10.1016/S0960-894X(02)00240-8.

J. Rousell, E.B. Haddad, J.C. Mak, B.L. Webb, M.A. Giembycz and P.J. Barnes, Mol. Pharmacol., 49, 629 (1996).

I.V. Ukrainets, V.O. Gorokhova, A.P. Benzuglyi and V.L. Sidorenko, Farm. Zh., 1, 75 (2000).

Y. Zhang, B.Q. Zou, K. Wang, Y.M. Pan, H. Liang, X.H. Yi and H.S. Wang, Med. Chem. Res., 21, 1341 (2012); doi:10.1007/s00044-011-9648-7.

S. Rubino, S. Petruso, R. Pierattelli, G. Bruno, G.C. Stocco, L. Steardo, M. Motta, M. Passerotto, E.D. Giudice and G. Gulì, J. Inorg. Biochem., 98, 2071 (2004); doi:10.1016/j.jinorgbio.2004.09.012.

M. Botta, S. Armaroli, D. Castagnolo, G. Fontana, P. Pera and E. Bombardelli, Bioorg. Med. Chem. Lett., 17, 1579 (2007); doi:10.1016/j.bmcl.2006.12.101

Issue

Vol. 26 No. 21 (2014): Vol 26 Issue 21

Synthesis and Antitumor Activities of Some 2-Oxo-quinoline-3-Schiff Base Derivatives

Corresponding Author(s) : Ye Zhang

Abstract

Keywords

Full Article

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References

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