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Vol. 26 No. 21 (2014): Vol 26 Issue 21

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Behaviour of Biosurfactant Iturin A at Liquid-Liquid Interface

https://doi.org/10.14233/ajchem.2014.16559
Arpita Yadav
Department of Chemical Engineering, University Institute of Engineering and Technology, Chhatrapati Shahu Ji Maharaj University, Kanpur-208 024, India ; Department of Chemistry, University Institute of Engineering and Technology, Chhatrapati Shahu Ji Maharaj University, Kanpur-208 024, India
Praveen Bhai Patel
Department of Chemical Engineering, University Institute of Engineering and Technology, Chhatrapati Shahu Ji Maharaj University, Kanpur-208 024, India ; Department of Chemistry, University Institute of Engineering and Technology, Chhatrapati Shahu Ji Maharaj University, Kanpur-208 024, India
Dhruv Bhaskar
Department of Chemical Engineering, University Institute of Engineering and Technology, Chhatrapati Shahu Ji Maharaj University, Kanpur-208 024, India ; Department of Chemistry, University Institute of Engineering and Technology, Chhatrapati Shahu Ji Maharaj University, Kanpur-208 024, India
Antara Banerjee
Department of Chemical Engineering, University Institute of Engineering and Technology, Chhatrapati Shahu Ji Maharaj University, Kanpur-208 024, India ; Department of Chemistry, University Institute of Engineering and Technology, Chhatrapati Shahu Ji Maharaj University, Kanpur-208 024, India
Sadhana Sachan
Department of Chemical Engineering, Motilal Nehru National Institute of Technology, Allahabad-211 004, India

Corresponding Author(s) : Arpita Yadav

arpitayadav@yahoo.co.in

Asian Journal of Chemistry, Vol. 26 No. 21 (2014): Vol 26 Issue 21

Abstract

ab initio molecular orbital calculations combined with molecular dynamics simulations have been performed on biosurfactant Iturin A. Intermolecular interaction results indicate that self aggregation of Iturin A is thermodynamically favored even in gas phase. In presence of a medium it will be further facilitated. Inverted micellar formation is predicted to be a spontaneous process and must occur at oil-water interface keeping polar heads towards water surface. Elucidation of this mode of action will complement research in designing pepfactants with synthetic ease and industrial applications. Biosurfactants are widely used in membrane stabilization studies and biotechnology experiments. Simulations carried out in this study indicate that these compounds can be used to enhance delivery of nuclear targeted drugs, in particular as anticancer agents, because they form a polar core and outer hydrophobic surface when self aggregating at lipid interface.

Keywords

Iturin A Biosurfactant Liquid-liquid interface
Yadav, A., Bhai Patel, P., Bhaskar, D., Banerjee, A., & Sachan, S. (2014). Behaviour of Biosurfactant Iturin A at Liquid-Liquid Interface. Asian Journal of Chemistry, 26(21), 7191–7195. https://doi.org/10.14233/ajchem.2014.16559
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