Interaction of Bivalent Transition Metal(II) Ions with Substituted Pyrimidines: Mixed Ligand Complexes of Co(II), Cu(II), Ni(II) &amp; Zn(II) with 5-Fluorouracil and Some Amines

S. Salon Mary; J. Dharmaraja; S. Arvind Narayan; Sutha Shobana

doi:10.14233/ajchem.2014.16524

Issue

Vol. 26 No. 21 (2014): Vol 26 Issue 21

Issue Published : September 30, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

Interaction of Bivalent Transition Metal(II) Ions with Substituted Pyrimidines: Mixed Ligand Complexes of Co(II), Cu(II), Ni(II) & Zn(II) with 5-Fluorouracil and Some Amines

https://doi.org/10.14233/ajchem.2014.16524

S. Salon Mary

Department of Chemistry, Gulf Model School, Al Muhaisnah, Qusais-13683, Dubai, UAE

J. Dharmaraja

Division of Chemistry, Faculty of Science and Humanities, Sree Sowdambika College of Engineering, Chettikurichi, Aruppukottai-626 134, India

S. Arvind Narayan

Division of Science and Humanities, K.N.S.K. College of Engineering, Therekalputhoor, Nagercoil-629 901, India

Sutha Shobana

Department of Chemistry, Rajas Institute of Technology for Women, Ozhuginasery, Nagercoil-629 001, India

Corresponding Author(s) : Sutha Shobana

shobanasubam@gmail.com

Asian Journal of Chemistry, Vol. 26 No. 21 (2014): Vol 26 Issue 21
Article Published : September 30, 2014

Abstract

In this work we explored the synthesis of twelve transition metal mixed ligand complexes (1-12). A new series of 5-fluorouracil (5-FU) with some amines namely ethylenediamine(en)/1,3-diaminopropane(1,3-dp)/ortho-phenylenediamine (opd) of general formulae [MAB (OAc) (H₂O)], where M = Co(II), Cu(II), Ni(II) & Zn(II), A = 5-FU and B = en/1,3-dp/opd are presented. Micro elemental analysis, IR and UV were used to characterize these complexes. The antioxidative activity was also tested.

Keywords

5-Fluorouracil Amines Cobalt(II) Copper(II) Ni(II) Zn(II) Antioxidative

Salon Mary, S., Dharmaraja, J., Arvind Narayan, S., & Shobana, S. (2014). Interaction of Bivalent Transition Metal(II) Ions with Substituted Pyrimidines: Mixed Ligand Complexes of Co(II), Cu(II), Ni(II) & Zn(II) with 5-Fluorouracil and Some Amines. Asian Journal of Chemistry, 26(21), 7133–7137. https://doi.org/10.14233/ajchem.2014.16524

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References

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References

N. Kaiser, A. Kimpfler, U. Massing, A.M. Burger, H.H. Fiebig, M. Brandl and R. Schubert, Int. J. Pharm., 256, 123 (2003); doi:10.1016/S0378-5173(03)00069-3.

G.M. Blackburn and M.J. Gait, Nucleic Acids in Chemistry & Biology, Oxford University Press, New York (1996).

S. Shobana, J. Dharmaraja and S. Selvaraj, International Conference on Biologically Active Molecules (ICBAM-2012), p. 272 (2012).

C. Heidelberger, P.V. Danenberg and R.G. Moran, in ed.: A. Meister, Fluorinated Pyrimidines and Their Nucleosides, In: Advances in Enzymology and Related Areas of Molecular Biology, John Wiley & Sons, New York, p. 57 (1983).

J.L. Grem, Invest. New Drugs, 18, 299 (2000); doi:10.1023/A:1006416410198.

D.M. Thomas and J.R. Zalcberg, Clin. Exp. Pharmacol. Physiol., 25, 887 (1998); doi:10.1111/j.1440-1681.1998.tb02339.x.

S. Shobana, J. Dharmaraja, P. Kamatchi and S. Selvaraj, J. Chem. Pharm. Res., 4, 499 (2012).

G. Weckbecker, Pharmacol. Ther., 50, 367 (1991); doi:10.1016/0163-7258(91)90051-M.

S. Shobana, J. Dharmaraja, S. Selvaraj and P. Subramaniam, International Conference on Perspectives in Vibrational Spectroscopy (ICOPVS-2013), pp. 25-26 (2012).

A. Weissenburg, E.S. Proskaur, J.A. Riddick and E.E. Toope Jr., Organic Solvents in Techniques of Organic Chemistry, Interscience, New York, edn 3 (1955).

A. Earnshaw, Introduction of Magnetochemistry, Academic Press, London (1968).

W.J. Geary, Coord. Chem. Rev., 7, 81 (1971); doi:10.1016/S0010-8545(00)80009-0.

S. Shobana, J. Dharmaraja and S. Selvaraj, Spectrochim. Acta A, 107, 117 (2013); doi:10.1016/j.saa.2013.01.024.

K. Nakamato, Infrared and Raman Spectra of Inorganic and Coordination Compounds, Wiley Interscience, New York (1986).

J. Dharmaraja, T. Esakkidurai, P. Subbaraj and S. Shobana, Spectrochim. Acta A, 114, 607 (2013); doi:10.1016/j.saa.2013.05.043.

C.J. Ballhausen, Introduction to Ligand Field Theory, McGraw-Hill, New York (1962).

M.A. Neelakantan, F. Rusalraj, J. Dharmaraja, S. Johnsonraja, T. Jeyakumar and M.S. Pillai, Spectrochim. Acta A, 71, 1599 (2008).

B.N. Figgs, Introduction to Ligand Field, New York, Wiley (1966).

A.B.P. Lever, Inorganic Electronic Spectroscopy (Elsvier, Amsterdam) p. 252 (1968).

V. Ponti, M.U. Dianzani, K. Cheeseman and T.F. Slater, Chem. Biol. Interact., 23, 281 (1978); doi:10.1016/0009-2797(78)90090-X.