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Vol. 26 No. 20 (2014)

Copyright (c) 2014 Fatin Nur Ain Abdul Rashid1, Asnuzilawati Asari1, Habsah Mohamad2, Siti Mariam Mohd Nor3

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Antibacterial Study of Aaptamine Derivatives

https://doi.org/10.14233/ajchem.2014.17377
Fatin Nur Ain Abdul Rashid1
1School of Fundamental Science, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia 2Institute of Marine Biotechnology, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia 3Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia *Corresponding author: E-mail: asnu@umt.edu.my
Asnuzilawati Asari1
1School of Fundamental Science, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia 2Institute of Marine Biotechnology, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia 3Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia *Corresponding author: E-mail: asnu@umt.edu.my
Habsah Mohamad2
1School of Fundamental Science, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia 2Institute of Marine Biotechnology, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia 3Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia *Corresponding author: E-mail: asnu@umt.edu.my
Siti Mariam Mohd Nor3
1School of Fundamental Science, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia 2Institute of Marine Biotechnology, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia 3Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia *Corresponding author: E-mail: asnu@umt.edu.my

Corresponding Author(s) : Fatin Nur Ain Abdul Rashid1

Asian Journal of Chemistry, Vol. 26 No. 20 (2014)

Abstract

Aaptamine is a bioactive marine alkaloid containing a unique of 1H-benzo[de][1,6]naphthyridine skeleton. Aaptamine was isolated from marine sponge, Aaptos aaptos and was proposed as starting material for semi-synthetic modifications. A series of aaptamine derivatives were synthesized which consisted of 1,4-dialkyl (2-7), 4-alkyl (8-10) and 9-O-butyryl-1,4-dialkyl (11-16) aaptamine derivatives. Each derivative was characterized by FT-IR, UV-visible, NMR and MS. The synthesized compounds were evaluated for their antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Bacillus cereus, Staphylococcus aureus and Micrococcus sp. bacterial strains using the disc-diffusion method. Some of the derivatives showed potent antibacterial activity against certain bacterial strains.

Keywords

Aaptamine Antibacterial Disc-diffussion method.
Nur Ain Abdul Rashid1, F., Asari1, A., Mohamad2, H., & Mariam Mohd Nor3, S. (2014). Synthesis and Antibacterial Study of Aaptamine Derivatives. Asian Journal of Chemistry, 26(20), 6903–6907. https://doi.org/10.14233/ajchem.2014.17377
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