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Vol. 26 No. 19 (2014): Vol 26 Issue 19

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Determination of Prilocaine HCl in Pharmaceutical Preparations by GC-MS Method

https://doi.org/10.14233/ajchem.2014.17150
Alptug Atila
Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, 25240 Erzurum, Turkey
Yucel Kadioglu
Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, 25240 Erzurum, Turkey

Corresponding Author(s) : Yucel Kadioglu

yucelkadi@yahoo.com

Asian Journal of Chemistry, Vol. 26 No. 19 (2014): Vol 26 Issue 19

Abstract

The novel analytical method using gas chromatography with mass spectrometry detection (GC-MS) method for determination of prilocaine HCl in pharmaceutical preparations were developed and validated. The using lidocaine HCl as the internal standard (IS) was carried out on HP-5MS capillary column. The calibration curves were linear (R = 0.999) in concentration range of 40-1000 ng/mL of prilocaine HCl. The LOD and LOQ values were 15 and 31 ng/mL, respectively. The within- and between-day RSD and RE % values of proposed method were found to be £ 3.4 and £ 3.5 %, respectively. o-Toluidine was formed in stored on auto sampler during 72 h was determined by proposed method. The developed method can be directly and easily applied for determination of prilocaine HCl without derivatized in pharmaceutical preparations using internal standard methodology.

Keywords

GC-MS method Prilocaine HCl Pharmaceutical preparations Validation
Atila, A., & Kadioglu, Y. (2014). Determination of Prilocaine HCl in Pharmaceutical Preparations by GC-MS Method. Asian Journal of Chemistry, 26(19), 6650–6654. https://doi.org/10.14233/ajchem.2014.17150
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