A Novel CCAG Hydrogel: The Mechanical Strength and Crosslinking Densities

Xian Li; Daidi Fan

doi:10.14233/ajchem.2014.16608

Issue

Vol. 26 No. 19 (2014): Vol 26 Issue 19

Issue Published : September 16, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

A Novel CCAG Hydrogel: The Mechanical Strength and Crosslinking Densities

https://doi.org/10.14233/ajchem.2014.16608

Xian Li

Shaanxi Key Laboratory of Degradable Biomedical Materials, Department of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, P.R. China

Daidi Fan

Shaanxi Key Laboratory of Degradable Biomedical Materials, Department of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, P.R. China

Corresponding Author(s) : Daidi Fan

fandaidi@nwu.edu.cn

Asian Journal of Chemistry, Vol. 26 No. 19 (2014): Vol 26 Issue 19
Article Published : September 19, 2014

Abstract

In this study, swelling behaviour and mechanical properties of the CS-HLC-HA/b-GP (chitosan-human like collagen-hyaluronic acid/b-sodium glycerophosphate) hydrogels, were investigated. The pH/temperature sensitive CCAG (CS-HLC-HA/b-GP) hydrogels were successfully synthesized by a combination of CCA (CS-HLC-HA) and b-GP by self-assemble technique. Compression-strain measurements were used to analyze the mechanical properties of the hydrogels. It was found that increasing the amount of hyaluronic acid comonomer in the gel structure increases the compression modulus of the materials. The results of mechanical measurements were used to characterize the network structure of the hydrogels, namely the effective crosslinking density (r). It was found that r increasing calculated from the initial amount of hyaluronic acid used for hydrogel synthesis. These hydrogels demonstrated dual sensitivity to both pH and temperature. It showed that the pH-sensitive or temperature-sensitive phase transition behaviour of the gels can be changed by changing the temperature or pH of the swelling medium at constant hydrogel composition. Finally, the results of equilibrium swelling and compression-strain measurements were used to calculate the interaction parameters of these hydrogels using a gel strength instrument.

Keywords

Hydrogel Mechanical strength Crosslinking densities Chitosan Hyaluronic acid β-Sodium glycerophosphate

Li, X., & Fan, D. (2014). A Novel CCAG Hydrogel: The Mechanical Strength and Crosslinking Densities. Asian Journal of Chemistry, 26(19), 6567–6570. https://doi.org/10.14233/ajchem.2014.16608

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References

R. Yoshida, K. Sakai, T. Okano and Y. Sakurai, Adv. Drug Deliv. Rev., 11, 85 (1993); doi:10.1016/0169-409X(93)90028-3.

X. Li, X.X. Ma, D.D. Fan and C.H. Zhu, Soft Matter, 8, 3781 (2012); doi:10.1039/c2sm06994f.

E.S. Gil and S. Hudson, Prog. Polym. Sci., 29, 1173 (2004); doi:10.1016/j.progpolymsci.2004.08.003.

J. Kost, in ed.: E. Mathiowitz, Intelligent Drug Delivery Systems; In: Encyclopaedia of Controlled Drug Delivery, John Wiley & Sons: New York, pp. 445-459 (1999).

A.S. Hoffman, J. Control. Release, 6, 297 (1987); doi:10.1016/0168-3659(87)90083-6.

A. Suzuki and T. Tanaka, Nature, 346, 345 (1990); doi:10.1038/346345a0.

M. Torres-Lugo and N.A. Peppas, Macromolecules, 32, 6646 (1999); doi:10.1021/ma990541c.

T. Tanaka, I. Nishio, S.T. Sun and S. Ueno-Nishio, Science, 218, 467 (1982); doi:10.1126/science.218.4571.467.

T. Miyata, N. Asami and T. Uragami, Nature, 399, 766 (1999); doi:10.1038/21619.

Y. Hirokawa and T. Tanaka, J. Chem. Phys., 81, 6379 (1984); doi:10.1063/1.447548.

X.Z. Zhang and R.X. Zhuo, Langmuir, 17, 12 (2001); doi:10.1021/la000170p.

L.E. Bromberg and E.S. Ron, Adv. Drug Deliv. Rev., 31, 197 (1998); doi:10.1016/S0169-409X(97)00121-X.

X.Z. Zhang, D.Q. Wu and C.C. Chu, Biomaterials, 25, 3793 (2004); doi:10.1016/j.biomaterials.2003.10.065.

X.D. Xu, H. Wei, X.Z. Zhang, S.X. Cheng and R.X. Zhuo, J. Biomed. Mater. Res. A, 81A, 418 (2007); doi:10.1002/jbm.a.31063.

A. Chenite, C. Chaput, D. Wang, C. Combes, M.D. Buschmann, C.D. Hoemann, J.C. Leroux, B.L. Atkinson, F. Binette and A. Selmani, Biomaterials, 21, 2155 (2000); doi:10.1016/S0142-9612(00)00116-2.

Y. Huang, S. Onyeri, M. Siewe, A. Moshfeghian and S.V. Madihally, Biomaterials, 26, 7616 (2005); doi:10.1016/j.biomaterials.2005.05.036.

H. Sashiwa, N. Kawasaki, A. Nakayama, E. Muraki, N. Yamamoto and S. Aiba, Biomacromolecules, 3, 1126 (2002); doi:10.1021/bm0200480.

L.Y. Chen, Z.G. Tian and Y.M. Du, Biomaterials, 25, 3725 (2004); doi:10.1016/j.biomaterials.2003.09.100.

Y.H. Lin, H.F. Liang, C.K. Chung, M.C. Chen and H.W. Sung, Biomaterials, 26, 2105 (2005); doi:10.1016/j.biomaterials.2004.06.011.

J. Ngoenkam, A. Faikrua, S. Yasothornsrikul and J. Viyoch, Int. J. Pharm., 391, 115 (2010); doi:10.1016/j.ijpharm.2010.02.028.

W.F. Lee and Y.J. Chen, J. Appl. Polym. Sci., 82, 2487 (2001); doi:10.1002/app.2099.

S.C. Tjong and J.Z. Bei, Polym. Eng. Sci., 38, 392 (1998); doi:10.1002/pen.10200.

X. Li, D.D. Fan, X.X. Ma, C.H. Zhu, Y. Luo, B.W. Liu and L. Chen, Soft Mater., 12, 1 (2014); doi:10.1080/1539445X.2011.584269.

Issue

Vol. 26 No. 19 (2014): Vol 26 Issue 19

A Novel CCAG Hydrogel: The Mechanical Strength and Crosslinking Densities

Corresponding Author(s) : Daidi Fan

Abstract

Keywords

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