A New Cytotoxic Xanthone from Hypericum chinense

Wenxiu Xu; Yanqing Ye; Haiyin Yang; Xuemei Gao; Qiufen Hu; Yadong Guo

doi:10.14233/ajchem.2014.16374

Issue

Vol. 26 No. 19 (2014): Vol 26 Issue 19

Issue Published : September 16, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

A New Cytotoxic Xanthone from Hypericum chinense

https://doi.org/10.14233/ajchem.2014.16374

Wenxiu Xu

School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, P.R. China

Yanqing Ye

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Haiyin Yang

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Xuemei Gao

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Qiufen Hu

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Yadong Guo

School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, P.R. China

Corresponding Author(s) : Yadong Guo

yadong_guo@yahoo.com.cn

Asian Journal of Chemistry, Vol. 26 No. 19 (2014): Vol 26 Issue 19
Article Published : September 18, 2014

Abstract

A new xanthone, 1,8-dihydroxy-4-(2-hydroxyethyl)-3-methoxy-9H-xanthen-9-one (1) was isolated from the leaves and stems of Hypericum chinense. Its structure was elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compound 1 was tested for its cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3 and MCF7) and it showed high cytotoxicity against PC3 and SHSY5Y cell with IC₅₀ values of 3.5 and 2.4 μM, respectively.

Keywords

Cytotoxic Xanthone Hypericum chinese

Xu, W., Ye, Y., Yang, H., Gao, X., Hu, Q., & Guo, Y. (2014). A New Cytotoxic Xanthone from Hypericum chinense. Asian Journal of Chemistry, 26(19), 6367–6369. https://doi.org/10.14233/ajchem.2014.16374

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Issue

Vol. 26 No. 19 (2014): Vol 26 Issue 19

A New Cytotoxic Xanthone from Hypericum chinense

Corresponding Author(s) : Yadong Guo

Abstract

Keywords

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