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Influence of Hydroxyl Groups of Quaternized Chitosan Derivatives on Antioxidant Activity
Corresponding Author(s) : Zhanyong Guo
Asian Journal of Chemistry,
Vol. 26 No. 16 (2014): Vol 26 Issue 16
Abstract
Four quaternized chitosan derivatives i.e., N-phenmethyl-N,N-dimethyl chitosan, N-(2-hydroxyl-phenmethyl)-N,N-dimethyl chitosan, N-(4-hydroxyl-phenmethyl)-N,N-dimethyl chitosan and N-(3,4-dihydroxyl-phenmethyl)-N,N-dimethyl chitosan were synthesized and their antioxidant activity against hydroxyl radicals was assessed. The result indicated that all the quaternized chitosan derivatives have better hydroxyl radical scavenging activity than chitosan and the antioxidant activity of derivatives increases when more hydroxyl groups are grafted.
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- R.A.A. Muzzarelli, Carbohydr. Polym., 8, 1 (1988); doi:10.1016/0144-8617(88)90032-X.
- K. Kurita, Prog. Polym. Sci., 26, 1921 (2001); doi:10.1016/S0079-6700(01)00007-7.
- Y. Zheng, Y. Yi, Y.P. Qi, Y.T. Wang, W.A. Zhang and M. Du, Bioorg. Med. Chem. Lett., 16, 4127 (2006); doi:10.1016/j.bmcl.2006.04.077.
- J. Jung and Y. Zhao, Bioorg. Med. Chem., 20, 2905 (2012); doi:10.1016/j.bmc.2012.03.020.
- Z.Y. Guo, H.Y. Liu, X.L. Chen, X. Ji and P.C. Li, Bioorg. Med. Chem. Lett., 16, 6348 (2006); doi:10.1016/j.bmcl.2006.09.009.
- K.C. Li, R.E. Xing, S. Liu, R.F. Li, Y.K. Qin, X.T. Meng and P.C. Li, Carbohydr. Polym., 88, 896 (2012); doi:10.1016/j.carbpol.2012.01.033.
- R.E. Xing, S. Liu, H.H. Yu, Z.Y. Guo, Z.E. Li and P.C. Li, Carbohydr. Polym., 61, 148 (2005); doi:10.1016/j.carbpol.2005.04.007.
- Z.Y. Guo, R.E. Xing, S. Liu, H.H. Yu, P.B. Wang, C.P. Li and P. Li, Bioorg. Med. Chem. Lett., 15, 4600 (2005); doi:10.1016/j.bmcl.2005.06.095.
- A. Winata and K. Lorenz, J. Food Process. Pres., 20, 417 (1996); doi:10.1111/j.1745-4549.1996.tb00757.x.
- Z.S. Jia, D.F. Shen and W.L. Xu, Carbohydr. Res., 333, 1 (2001); doi:10.1016/S0008-6215(01)00112-4.
- J.C. Wang, G.S. Xing, W.D. Hu, T.L. Zhu, Q. Wang and H. Zhao, Chin. Pharm. J., 29, 23 (1994).
References
R.A.A. Muzzarelli, Carbohydr. Polym., 8, 1 (1988); doi:10.1016/0144-8617(88)90032-X.
K. Kurita, Prog. Polym. Sci., 26, 1921 (2001); doi:10.1016/S0079-6700(01)00007-7.
Y. Zheng, Y. Yi, Y.P. Qi, Y.T. Wang, W.A. Zhang and M. Du, Bioorg. Med. Chem. Lett., 16, 4127 (2006); doi:10.1016/j.bmcl.2006.04.077.
J. Jung and Y. Zhao, Bioorg. Med. Chem., 20, 2905 (2012); doi:10.1016/j.bmc.2012.03.020.
Z.Y. Guo, H.Y. Liu, X.L. Chen, X. Ji and P.C. Li, Bioorg. Med. Chem. Lett., 16, 6348 (2006); doi:10.1016/j.bmcl.2006.09.009.
K.C. Li, R.E. Xing, S. Liu, R.F. Li, Y.K. Qin, X.T. Meng and P.C. Li, Carbohydr. Polym., 88, 896 (2012); doi:10.1016/j.carbpol.2012.01.033.
R.E. Xing, S. Liu, H.H. Yu, Z.Y. Guo, Z.E. Li and P.C. Li, Carbohydr. Polym., 61, 148 (2005); doi:10.1016/j.carbpol.2005.04.007.
Z.Y. Guo, R.E. Xing, S. Liu, H.H. Yu, P.B. Wang, C.P. Li and P. Li, Bioorg. Med. Chem. Lett., 15, 4600 (2005); doi:10.1016/j.bmcl.2005.06.095.
A. Winata and K. Lorenz, J. Food Process. Pres., 20, 417 (1996); doi:10.1111/j.1745-4549.1996.tb00757.x.
Z.S. Jia, D.F. Shen and W.L. Xu, Carbohydr. Res., 333, 1 (2001); doi:10.1016/S0008-6215(01)00112-4.
J.C. Wang, G.S. Xing, W.D. Hu, T.L. Zhu, Q. Wang and H. Zhao, Chin. Pharm. J., 29, 23 (1994).