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Vol. 26 No. 14 (2014): Vol 26 Issue 14

Copyright (c) 2014 AJC

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Two-Step Synthesis of Some Novel Monoindolylmaleimides

https://doi.org/10.14233/ajchem.2014.16751
Jian Zhong
College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, P.R. China; These authors contributed equally
Ping Jia
College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, P.R. China; These authors contributed equally
Shan Xu
College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, P.R. China
Liang Han
College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, P.R. China
Yujing Li
College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, P.R. China
Jianrong Gao
College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, P.R. China
Qing Ye
College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, P.R. China

Corresponding Author(s) : Qing Ye

yeqing1975@zjut.edu.cn; yeqing1975@yeah.net

Asian Journal of Chemistry, Vol. 26 No. 14 (2014): Vol 26 Issue 14

Abstract

Monoindolylmaleimides have been identified as potent glycogen synthase kinase-3b inhibitors. In this paper, a convenient methodology for the preparation of some new monoindolylmaleimides was developed by microwave assisted condensation of substituted monochloromaleimides with N-containing heterocycles followed by ammonolysis in good overall yield (up to 80 %). The products were characterized by 1H NMR and ESI-MS.

Keywords

Monindolylmaleimides Microwave assisted condensation Microwave assisted ammonolysis GSK-3β inhibitors
Zhong, J., Jia, P., Xu, S., Han, L., Li, Y., Gao, J., & Ye, Q. (2014). Two-Step Synthesis of Some Novel Monoindolylmaleimides. Asian Journal of Chemistry, 26(14), 4399–4404. https://doi.org/10.14233/ajchem.2014.16751
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