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Vol. 26 No. 14 (2014): Vol 26 Issue 14

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Isolation, Docking and Cytotoxicity Evaluation Against Cholangiocarcinoma of Labdanes from Curcuma petiolata

https://doi.org/10.14233/ajchem.2014.16258
Jittra Suthiwong
Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand
Siripit Pitchuanchom
Laboratory of Natural Products, Faculty of Science and Center of Excellence for Innovation in Chemistry, Lampang Rajabhat University, Lampang, 52100, Thailand
Wareeporn Wattanawongdon
Department of Microbiology, Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
Chariya Hahnvajanawong
Department of Microbiology, Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
Chavi Yenjai
Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand

Corresponding Author(s) : Chavi Yenjai

chayen@kku.ac.th

Asian Journal of Chemistry, Vol. 26 No. 14 (2014): Vol 26 Issue 14

Abstract

Labdanes 1-4, stigmasterol (5) and vanillin (6) were isolated from the rhizomes of Curcuma petiolata. Compounds 2-4 exhibited strong to moderate cytotoxicity against cholangiocarcinoma cell lines. Compound 3 showed strong cytotoxicity with IC50 values ranging from 5-11 μg/mL. The molecular modeling was studied using the AutoDock 4 program. The docking results reveal that 3 interacted with EGFR through the 2 H-bond at Gln767 and Met769 with binding energy of -6.89 kcal/mol.

Keywords

Curcuma petiolata Labdane Cholangiocarcinoma Epidermal growth factor receptor
Suthiwong, J., Pitchuanchom, S., Wattanawongdon, W., Hahnvajanawong, C., & Yenjai, C. (2014). Isolation, Docking and Cytotoxicity Evaluation Against Cholangiocarcinoma of Labdanes from Curcuma petiolata. Asian Journal of Chemistry, 26(14), 4286–4290. https://doi.org/10.14233/ajchem.2014.16258
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