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Vol. 26 No. 14 (2014): Vol 26 Issue 14

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Synthesis, Characterization and Bioevaluation of (Z)-4-Substituted phenyl-2-((2-oxoindolin-3-ylidene)aminocyclopent-1-ene carbodithioate) Derivatives from 2-Aminocyclopent-1-ene Carbodithioic Acid

https://doi.org/10.14233/ajchem.2014.16090
Y.L.N. Murthy
Department of Organic Chemistry, Andhra University, Visakhapatnam-530 003, India
Palla Mani
Department of Organic Chemistry, Andhra University, Visakhapatnam-530 003, India
Palla Mahesh
Department of Organic Chemistry, Andhra University, Visakhapatnam-530 003, India ; Jawaharlal Nehru Technological University, Hyderabad-500 085, India
K. Chaguruswamy
Department of Organic Chemistry, Andhra University, Visakhapatnam-530 003, India

Corresponding Author(s) : Y.L.N. Murthy

murthyyln@gmail.com

Asian Journal of Chemistry, Vol. 26 No. 14 (2014): Vol 26 Issue 14

Abstract

A series of oxoindoline derivatives 6(a-e) have been synthesized. Treatment of cyclopentanone (1) with carbon disulphide (2) in liq. NH3 yielded 2-amino-cyclopent-1-enecarbodithioic acid (3) which on further treatment with isatin (4) in ethanol under reflux conditions for 2 h gave (Z)-2-(2-oxoindolin)-aminocyclopentene carbodithioic acid (5). Compound 5 was treated with different 1,4 diaryl substituents in THF resulted the formation of the target molecule viz., oxoindoline derivatives 6(a-e). These compounds were evaluated in vitro antimicrobial activities by agar well dilution method. Oxoindoline derivatives exhibited the broad spectrum of antibacterial activity (compounds 3, 5, 6a, 6c, 6e) and mild activity (6b and 6d), besides potent antifungal activity.

Keywords

Indole Cyclopentanone THF Oxoindoline Antimicrobial activity
Murthy, Y., Mani, P., Mahesh, P., & Chaguruswamy, K. (2014). Synthesis, Characterization and Bioevaluation of (Z)-4-Substituted phenyl-2-((2-oxoindolin-3-ylidene)aminocyclopent-1-ene carbodithioate) Derivatives from 2-Aminocyclopent-1-ene Carbodithioic Acid. Asian Journal of Chemistry, 26(14), 4255–4258. https://doi.org/10.14233/ajchem.2014.16090
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