Copyright (c) 2014 AJC
This work is licensed under a Creative Commons Attribution 4.0 International License.
Hydroxypropyl-β-Cyclodextrin Functionalized Graphene Oxide Nanospheres as Unmodified Paclitaxel Carriers
Corresponding Author(s) : Guomin Xiao
Asian Journal of Chemistry,
Vol. 26 No. 14 (2014): Vol 26 Issue 14
Abstract
This work reports a novel type of electrosprayed graphene oxide nanospheres consisting of gelatin and hydroxypropyl-b-cyclodextrin functionalized graphene oxide sheets to support water insoluble anticancer drug paclitaxel. The drug loading content and drug loading efficiency were as high as 14.9 μg/mg and 59.5 %, respectively. The slow and smooth in-vitro release profiles of paclitaxel were assigned to the strong interaction between graphene oxide sheets and the hydroxypropyl-b-cyclodextrin molecules, in addition to the encapsulation of electrosprayed graphene oxide nanospheres.
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- J.M. Berlin, A.D. Leonard, T.T. Pham, D. Sano, D.C. Marcano, S. Yan, S. Fiorentino, Z.L. Milas, D.V. Kosynkin, B.K. Price, R.M. Lucente-Schultz, X.X. Wen, M.G. Raso, S.L. Craig, H.T. Tran, J.N. Myers and J.M. Tour, ACS Nano, 4, 4621 (2010); doi:10.1021/nn100975c.
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- K. Peng, I. Tomatsu, A.V. Korobko and A. Kros, Soft Matter, 6, 85 (2009); doi:10.1039/b914166a.
- W.S. Hummers Jr. and R.E. Offeman, J. Am. Chem. Soc., 80, 1339 (1958); doi:10.1021/ja01539a017.
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- S. Guo and S. Dong, Chem. Soc. Rev., 40, 2644 (2011); doi:10.1039/c0cs00079e.
- C. Xu, J. Wang, L. Wan, J. Lin and X. Wang, J. Mater. Chem., 21, 10463 (2011); doi:10.1039/c1jm10478k.
- K.N. Kudin, B. Ozbas, H.C. Schniepp, R.K. Prud'homme, I.A. Aksay and R. Car, Nano Lett., 8, 36 (2008); doi:10.1021/nl071822y.
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References
J.M. Berlin, A.D. Leonard, T.T. Pham, D. Sano, D.C. Marcano, S. Yan, S. Fiorentino, Z.L. Milas, D.V. Kosynkin, B.K. Price, R.M. Lucente-Schultz, X.X. Wen, M.G. Raso, S.L. Craig, H.T. Tran, J.N. Myers and J.M. Tour, ACS Nano, 4, 4621 (2010); doi:10.1021/nn100975c.
J.M. Berlin, T.T. Pham, D. Sano, K.A. Mohamedali, D.C. Marcano, J.N. Myers and J.M. Tour, ACS Nano, 5, 6643 (2011); doi:10.1021/nn2021293.
S. Li and M. Wang, Mater. Lett., 92, 350 (2013); doi:10.1016/j.matlet.2012.10.129.
T.A. Hilder and J.M. Hill, Micro & Nano Lett., 3, 41 (2008); doi:10.1049/mnl:20080008.
J. Zhang, Y. Liang, N. Li, X. Zhao, R. Hu, F. Hu, J. Xing, L. Deng and A. Dong, Micro & Nano Lett., 7, 183 (2012); doi:10.1049/mnl.2011.0580.
Y. Jing, Y. Zhu, X. Yang, J. Shen and C. Li, Langmuir, 27, 1175 (2011); doi:10.1021/la1042734.
X. Sun, Z. Liu, K. Welsher, J.T. Robinson, A. Goodwin, S. Zaric and H. Dai, Nano Res., 1, 203 (2008); doi:10.1007/s12274-008-8021-8.
Z. Liu, J.T. Robinson, X. Sun and H. Dai, J. Am. Chem. Soc., 130, 10876 (2008); doi:10.1021/ja803688x.
A. Celebioglu and T. Uyar, Chem. Commun., 46, 6903 (2010); doi:10.1039/c0cc01484b.
K. Peng, I. Tomatsu, A.V. Korobko and A. Kros, Soft Matter, 6, 85 (2009); doi:10.1039/b914166a.
W.S. Hummers Jr. and R.E. Offeman, J. Am. Chem. Soc., 80, 1339 (1958); doi:10.1021/ja01539a017.
A.K. Geim and K.S. Novoselov, Nat. Mater., 6, 183 (2007); doi:10.1038/nmat1849.
S. Guo and S. Dong, Chem. Soc. Rev., 40, 2644 (2011); doi:10.1039/c0cs00079e.
C. Xu, J. Wang, L. Wan, J. Lin and X. Wang, J. Mater. Chem., 21, 10463 (2011); doi:10.1039/c1jm10478k.
K.N. Kudin, B. Ozbas, H.C. Schniepp, R.K. Prud'homme, I.A. Aksay and R. Car, Nano Lett., 8, 36 (2008); doi:10.1021/nl071822y.
J.M. Englert, C. Dotzer, G. Yang, M. Schmid, C. Papp, J.M. Gottfried, H.P. Steinrück, E. Spiecker, F. Hauke and A. Hirsch, Nat. Chem., 3, 279 (2011); doi:10.1038/nchem.1010.