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Vol. 26 No. 13 (2014): Vol 26 Issue 13

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Simultaneous Estimation of Quinapril Hydrochloride and Hydrochlorothiazide from Pharmaceutical Formulation by Using UV, IR and RP-HPLC

https://doi.org/10.14233/ajchem.2014.15935
Vandana Tukaram Gawande
Department of Pharmaceutical Chemistry, STES's Sinhgad Institute of Pharmacy, Off. Smt. Kashibai Navale Hospital, Narhe, Pune-411041, India
Pankaj Birajlal Miniyar
Department of Pharmaceutical Chemistry, STES's Sinhgad Institute of Pharmacy, Off. Smt. Kashibai Navale Hospital, Narhe, Pune-411041, India
Deepali Dattatray Bhandari
Department of Pharmaceutical Chemistry, STES's Sinhgad Institute of Pharmacy, Off. Smt. Kashibai Navale Hospital, Narhe, Pune-411041, India
Manasi Kailas Ghag
Department of Pharmaceutical Chemistry, STES's Sinhgad Institute of Pharmacy, Off. Smt. Kashibai Navale Hospital, Narhe, Pune-411041, India
Dhananjaysingh Bhikamsingh Rajput
Department of Pharmaceutical Chemistry, STES's Sinhgad Institute of Pharmacy, Off. Smt. Kashibai Navale Hospital, Narhe, Pune-411041, India
Avinash Mahajan
Department of Pharmaceutical Chemistry, STES's Sinhgad Institute of Pharmacy, Off. Smt. Kashibai Navale Hospital, Narhe, Pune-411041, India

Corresponding Author(s) : Avinash Mahajan

anand_mahajan@yahoo.com

Asian Journal of Chemistry, Vol. 26 No. 13 (2014): Vol 26 Issue 13

Abstract

The objective of present investigation was to develop and validate assay methods for simultaneous estimation of quinapril hydrochloride and hydrochlorothiazide in combined dosage form by using three different analytical approaches viz. UV, FT-IR and RP-HPLC. Drugs were estimated by dual wavelength method and calibration curve methods by using UV and FT-IR spectrophotometer, respectively. The stability indicating assay method was developed by using HPLC. The stress degradation study was carried out according to International Conference on Harmonization (ICH) guideline Q1A (R2). Chromatographic separation was carried out on HIQ-Sil (150 × 4.6 mm, 5 μm) column using 0.01 M KH2PO4 buffer (pH 3.5, adjusted with orthophosphoric acid): methanol as mobile phase in gradient elution mode.

Keywords

Dual wavelength DRIFTS Hydrochlorothiazide Quinapril hydrochloride RP-HPLC
Tukaram Gawande, V., Birajlal Miniyar, P., Dattatray Bhandari, D., Kailas Ghag, M., Bhikamsingh Rajput, D., & Mahajan, A. (2014). Simultaneous Estimation of Quinapril Hydrochloride and Hydrochlorothiazide from Pharmaceutical Formulation by Using UV, IR and RP-HPLC. Asian Journal of Chemistry, 26(13), 3799–3804. https://doi.org/10.14233/ajchem.2014.15935
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