Thermo-Responsible Sol-Gel Transition of Bioabsorbable Hydrogels Consisting of Enantiomeric A-B-A Tri-Block Copolymers of Poly(lactic acid) (A) and Poly(oxypropylene-co-oxyethylene) (B)

Chanwoo Lee

doi:10.14233/ajchem.2014.17721

Issue

Vol. 26 No. 13 (2014): Vol 26 Issue 13

Issue Published : June 23, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

Thermo-Responsible Sol-Gel Transition of Bioabsorbable Hydrogels Consisting of Enantiomeric A-B-A Tri-Block Copolymers of Poly(lactic acid) (A) and Poly(oxypropylene-co-oxyethylene) (B)

https://doi.org/10.14233/ajchem.2014.17721

Chanwoo Lee

Department of Innovative Industrial Technology, Hoseo University, Asan, Chungnam 336-851, Republic of Korea

Corresponding Author(s) : Chanwoo Lee

cwlee@hoseo.edu

Asian Journal of Chemistry, Vol. 26 No. 13 (2014): Vol 26 Issue 13
Article Published : June 26, 2014

Abstract

For the purpose of controlling gelation rate of the above suspension, the A-B-A triblock copolymers system comprising PLLA-PN-PLLA and PDLA-PN-PDLA was synthesized using PN (Pluronic^®) in stead of PEG. Since PN is a non-ionic macromolecular surfactant that can aggregate into micelles in aqueous solution in itself, not only the stereocomplexation of PLLA and PDLA segments but also the phase change behaviour of PN are expected to comtribute to the sol-gel transition of the mixed suspension of enantiomeric copolymers to realize a sharp sol-gel change. Based on the results of these studies, we will discuss the changes in hydrophilic/hydrophobic balance in these copolymers that gives rise to the controlled gelation time and gel strength.

Keywords

Gelation Triblock copolymer Stereocomplexation Sol-gel transition Enantiomeric copolymer

Lee, C. (2014). Thermo-Responsible Sol-Gel Transition of Bioabsorbable Hydrogels Consisting of Enantiomeric A-B-A Tri-Block Copolymers of Poly(lactic acid) (A) and Poly(oxypropylene-co-oxyethylene) (B). Asian Journal of Chemistry, 26(13), 4087–4091. https://doi.org/10.14233/ajchem.2014.17721

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References

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C. W. Lee and Y. Kimura, Bull. Chem. Soc. Jpn., 69, 1787 (1996); doi:10.1246/bcsj.69.1787.
X.Y. Xiong, K.C. Tam and L.H. Gan, Macromolecules, 36, 9979 (2003); doi:10.1021/ma035292d.
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References

S.H. Kim, Y.-K. Han, K.-D. Ahn, Y.H. Kim and T. Chang, Makromol. Chem., 194, 3229 (1993); doi:10.1002/macp.1993.021941202.

P. De Santis and A.J. Kovacs, Biopolymer, 6, 299 (1968); doi:10.1002/bip.1968.360060305.

Y. Nagata and K. Kajiwara, Gel Handbook, NTS, Tokyo (1997).

B. Urman, V. Gomel and N. Jetha, Fertil. Steril., 56, 563 (1991).

G.A. Edwards, V. Glattauer, T.J. Nash, J.F. White, K.A. Brock, J.A. Werkmeister and J.A. Ramshaw, J. Biomed. Mater. Res., 34, 291 (1997); doi:10.1002/(SICI)1097-4636(19970305)34:3<291::AID-JBM3>3.0.CO;2-F.

K. Tomihata and Y. Ikada, Biomaterials, 18, 567 (1997); doi:10.1016/S0142-9612(96)00167-6.

C.W. Lee, T. Manoshiro, Y. Hsu and Y. Kimura, Macromol. Chem. Phys., 213, 2174 (2012); doi:10.1002/macp.201200375.

T. Fujiwara, T. Mukose, T. Yamaoka, H. Yamane, S. Sakurai and Y. Kimura, Macromol. Biosci., 1, 204 (2001); doi:10.1002/1616-5195(20010701)1:5<204::AID-MABI204>3.0.CO;2-H.

C. W. Lee and Y. Kimura, Bull. Chem. Soc. Jpn., 69, 1787 (1996); doi:10.1246/bcsj.69.1787.

X.Y. Xiong, K.C. Tam and L.H. Gan, Macromolecules, 36, 9979 (2003); doi:10.1021/ma035292d.

X.Y. Xiong, K.C. Tam and L.H. Gan, Macromolecules, 37, 3425 (2004); doi:10.1021/ma049662p.

X.Y. Xiong, K.C. Tam and L.H. Gan, Polymer, 46, 1841 (2005); doi:10.1016/j.polymer.2005.01.010.

S.M. Moghimi, Adv. Drug Deliv. Rev., 16, 183 (1995); doi:10.1016/0169-409X(95)00024-2.

A.V. Kabanov, P. Lemieux, S. Vinogradov and V.Y. Alakhov, Adv. Drug Deliv. Rev., 54, 223 (2002); doi:10.1016/S0169-409X(02)00018-2.

A.V. Kabanov, E.V. Batrakova and V.Y. Alakhov, Adv. Drug Deliv. Rev., 54, 759 (2002); doi:10.1016/S0169-409X(02)00047-9.

A.V. Kabanov, E.V. Batrakova and D.W. Miller, Adv. Drug Deliv. Rev., 55, 151 (2003); doi:10.1016/S0169-409X(02)00176-X.

Issue

Vol. 26 No. 13 (2014): Vol 26 Issue 13

Thermo-Responsible Sol-Gel Transition of Bioabsorbable Hydrogels Consisting of Enantiomeric A-B-A Tri-Block Copolymers of Poly(lactic acid) (A) and Poly(oxypropylene-co-oxyethylene) (B)

Corresponding Author(s) : Chanwoo Lee

Abstract

Keywords

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