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A Validated UV Spectroscopic Method for Simultaneous Determination of Benzil and Benzophenone Impurities in Phenytoin Sodium
Corresponding Author(s) : Pooja Korde
Asian Journal of Chemistry,
Vol. 26 No. 13 (2014): Vol 26 Issue 13
Abstract
A simple, accurate, precise, economical and reproducible UV spectrophotometric method has been developed for the simultaneous determination of benzophenone and benzil impurities in phenytoin sodium. The method employs formation and solving of simultaneous equation using 222, 257 and 263 nm as the analytical wavelengths. Method was found to be precise and was reproducible as shown from the validation studies.
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- S. Sweetman, Martindale: The Complete Drug Reference, The Pharmaceutical Press, London, p. 495 (2009).
- http://www.cdc.gov/niosh/ipcsneng/neng0389.html/international/chemical safety cards for benzophenone.
- British Pharmacopoeia Commission, The British Pharmacopoeia, The Stationery Office, London, vol. 2, pp. 1614-1615 (2009).
- United States Pharmacopeial Convention: The United States Pharmacopoeia 32, the National Formulary 27, Rockville, MD, USA, vol. 3, p. 3291 (2009).
- R.S. Chhabra, National Toxicology Program, 61, 6 (2000).
- M.C. Rhodes, J.R. Bucher, J.C. Peckham, G.E. Kissling, M.R. Hejtmancik and R.S. Chhabra, Food Chem. Toxicol., 45, 843 (2007); doi:10.1016/j.fct.2006.11.003.
- http://en.wikipedia.org/wiki/Benzil.
- http://www.spectrumchemical.com/MSDS/TCI-B0050.pdf/ Benzil Spectrum chemical.
- http://www.sciencelab.com/msds.php?msdsId=9923047/ MSDS for Benzil.
- Z. Jung and J. Silhankova, Farm. Obz., 47, 349 (1978).
- A. Khedr, M. Moustafa, A.B. Abdel-Naim, A. Alahda and H. Mosli, Anal. Chem. Insights, 3, 61 (2008).
- A. Varaprasad, N. Sriram, A.G.I. Blessing, M. Jawahar and S. Thangamuthu, Int. J. Biol. Pharm. Res., 3, 126 (2012).
- E. Seyhan, U. Ahmet and O. Tuncel, Hacettepe Universitesi Eczacilik Fakultesi Dergisi, 17, 55 (1997).
- O.A. Razak, A.A. Gazy and A.M. Wahbi, J. Pharm. Biomed. Anal., 28, 613 (2002); doi:10.1016/S0731-7085(01)00669-0.
- M. Walash, M. Rizk, Z. Sheribah and M. Salim, Chem. Cent. J., 5, 85 (2011); doi:10.1186/1752-153X-5-85.
- R. Sharma and K. Mehta, Indian J. Pharm. Sci., 72, 527 (2010); doi:10.4103/0250-474X.73926.
References
S. Sweetman, Martindale: The Complete Drug Reference, The Pharmaceutical Press, London, p. 495 (2009).
http://www.cdc.gov/niosh/ipcsneng/neng0389.html/international/chemical safety cards for benzophenone.
British Pharmacopoeia Commission, The British Pharmacopoeia, The Stationery Office, London, vol. 2, pp. 1614-1615 (2009).
United States Pharmacopeial Convention: The United States Pharmacopoeia 32, the National Formulary 27, Rockville, MD, USA, vol. 3, p. 3291 (2009).
R.S. Chhabra, National Toxicology Program, 61, 6 (2000).
M.C. Rhodes, J.R. Bucher, J.C. Peckham, G.E. Kissling, M.R. Hejtmancik and R.S. Chhabra, Food Chem. Toxicol., 45, 843 (2007); doi:10.1016/j.fct.2006.11.003.
http://en.wikipedia.org/wiki/Benzil.
http://www.spectrumchemical.com/MSDS/TCI-B0050.pdf/ Benzil Spectrum chemical.
http://www.sciencelab.com/msds.php?msdsId=9923047/ MSDS for Benzil.
Z. Jung and J. Silhankova, Farm. Obz., 47, 349 (1978).
A. Khedr, M. Moustafa, A.B. Abdel-Naim, A. Alahda and H. Mosli, Anal. Chem. Insights, 3, 61 (2008).
A. Varaprasad, N. Sriram, A.G.I. Blessing, M. Jawahar and S. Thangamuthu, Int. J. Biol. Pharm. Res., 3, 126 (2012).
E. Seyhan, U. Ahmet and O. Tuncel, Hacettepe Universitesi Eczacilik Fakultesi Dergisi, 17, 55 (1997).
O.A. Razak, A.A. Gazy and A.M. Wahbi, J. Pharm. Biomed. Anal., 28, 613 (2002); doi:10.1016/S0731-7085(01)00669-0.
M. Walash, M. Rizk, Z. Sheribah and M. Salim, Chem. Cent. J., 5, 85 (2011); doi:10.1186/1752-153X-5-85.
R. Sharma and K. Mehta, Indian J. Pharm. Sci., 72, 527 (2010); doi:10.4103/0250-474X.73926.