Protective Role of Arctium lappa Linn. against Arsenic Trioxide Using Silybum marianum Linn. as Standard Drug

Ann Susan Edison; Uma Maheswari Krishnan; Brindha Pemiah

doi:10.14233/ajchem.2014.17067A

Issue

Vol. 26 No. 12 (2014): Vol 26 Issue 12

Issue Published : June 5, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

Protective Role of Arctium lappa Linn. against Arsenic Trioxide Using Silybum marianum Linn. as Standard Drug

https://doi.org/10.14233/ajchem.2014.17067A

Ann Susan Edison

Centre for Advanced Research in Indian System of Medicine, SASTRA University, Thanjavur-613 401, India

Uma Maheswari Krishnan

Centre for Nanotechnology & Advanced Biomaterials, SASTRA University, Thanjavur-613 401, India

Brindha Pemiah

Centre for Advanced Research in Indian System of Medicine, SASTRA University, Thanjavur-613 401, India

Corresponding Author(s) : Ann Susan Edison

umakrishnan@sastra.edu

Asian Journal of Chemistry, Vol. 26 No. 12 (2014): Vol 26 Issue 12
Article Published : June 6, 2014

Abstract

Continuous exposure of humans to arsenic through long term ingestion of contaminated water and food leads to serious health problems. We have investigated the protective role of Arctium lappa extract against arsenic trioxide using Silybum marianum as standard in Wistar rats. Wistar rats were administered arsenic trioxide (5 and 10 mg/kg) by oral gavage for 30 and 60 days. Results established a significant increase in certain biochemical parameters such as alkaline phosphatase, serum glutamate oxaloacetate transminase, serum glutamate pyruvate transaminase, urea and creatinine. Significant increase and decrease in haematological parameters such as lymphocytes erythrocytes were reported. Certain histopathological lesions were also seen in arsenic induced rats. Silybum marianum and Arctium lappa at a dosage of (30 and 50 mg/kg) significantly normalized body weights, haematological and biochemical profiles in arsenic treated rats. This study demonstrates that Arctium lappa exhibits a protective role against arsenic trioxide and is as efficient as Silybum marianum.

Keywords

Arsenic trioxide Silybum marianum Arctium lappa Detoxification Biochemical Haematology Histopathology

Susan Edison, A., Maheswari Krishnan, U., & Pemiah, B. (2014). Protective Role of Arctium lappa Linn. against Arsenic Trioxide Using Silybum marianum Linn. as Standard Drug. Asian Journal of Chemistry, 26(12), 3749–3753. https://doi.org/10.14233/ajchem.2014.17067A

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References

M.L. Kile and D.C. Christiani, JAMA, 300, 845 (2008); doi:10.1001/jama.300.7.845.

A. Navas-Acien, JAMA, 300, 814 (2008); doi:10.1001/jama.300.7.814.

A. Manimaran, S.N. Sarkar and P. Sankar, Food Chem. Toxicol., 48, 605 (2010); doi:10.1016/j.fct.2009.11.039.

R. Chowdhury, A. Dutta, S.R. Chaudhuri, N. Sharma, A.K. Giri and K. Chaudhuri, Food Chem. Toxicol., 46, 740 (2008); doi:10.1016/j.fct.2007.09.108.

M.J. Mass, A. Tennant, B.C. Roop, W.R. Cullen, M. Styblo, D.J. Thomas and A.D. Kligerman, Chem. Res. Toxicol., 14, 355 (2001); doi:10.1021/tx000251l.

M. Gielen and E.R. Tiekink, Metallotherapeutic Drugs and Metal-Based Diagnostic Agents, Wiley, p. 298 (2005).

M.J. Gresser, J. Biol. Chem., 256, 5981 (1981).

T. Gebel, Toxicology, 144, 155 (2000); doi:10.1016/S0300-483X(99)00202-4.

L.M. Del Razo and B. Quintanilla-Vega, Toxicol. Appl. Pharmacol., 177, 132 (2001); doi:10.1006/taap.2001.9291.

H. Greenlee, K. Abascal, E. Yarnell and E. Ladas, Integr. Cancer Ther., 6, 158 (2007); doi:10.1177/1534735407301727.

J. Dai, R.S. Weinberg, S. Waxman and Y. Jing, Blood, 93, 268 (1999).

M. Vahter and G. Concha, Pharmacol. Toxicol., 89, 1 (2001); doi:10.1111/j.1600-0773.2001.890101.x.

K.T. Kitchin, Toxicol. Appl. Pharmacol., 172, 249 (2001); doi:10.1006/taap.2001.9157.

F.S. Hogan, N.K. Krishnegowda, M. Mikhailova and M.S. Kahlenberg, J. Surg. Res., 143, 58 (2007); doi:10.1016/j.jss.2007.03.080.

J.J. Lah, W. Cui and K.-Q. Hu, World J. Gastroenterol., 13, 5299 (2007).

H.S. Kang, J.Y. Lee and C.J. Kim, J. Ethnopharmacol., 116, 305 (2008); doi:10.1016/j.jep.2007.11.030.

Issue

Vol. 26 No. 12 (2014): Vol 26 Issue 12

Protective Role of Arctium lappa Linn. against Arsenic Trioxide Using Silybum marianum Linn. as Standard Drug

Corresponding Author(s) : Ann Susan Edison

Abstract

Keywords

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