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Vol. 26 No. 12 (2014): Vol 26 Issue 12

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Fabrication of Hydrogel Beads Entrappted by Mesoporous Silicates Nanoparticles for pH-sensitive and Sustained Release of Indomethacin

https://doi.org/10.14233/ajchem.2014.16613
Zhijian Deng
The First Affiliated Hospital, Xinxiang Medical University, Xinxiang 453100, Henan Province, P.R. China
Wengzong Zhang
Laboratory of Cell Imaging, Henan University of Traditional Chinese Medicine, Zhengzhou 450002, Henan Province, P.R. China
Yizhong Lu
The First Affiliated Hospital, Xinxiang Medical University, Xinxiang 453100, Henan Province, P.R. China
Yongheng Zhang
The First Affiliated Hospital, Xinxiang Medical University, Xinxiang 453100, Henan Province, P.R. China
Zhongmin Lu
The First Affiliated Hospital, Xinxiang Medical University, Xinxiang 453100, Henan Province, P.R. China
Sujuan Pei
The First Affiliated Hospital, Xinxiang Medical University, Xinxiang 453100, Henan Province, P.R. China

Corresponding Author(s) : Zhijian Deng

dengzhijian70@sina.com

Asian Journal of Chemistry, Vol. 26 No. 12 (2014): Vol 26 Issue 12

Abstract

In this study, hydrophobic indomethacin was quantitative loaded onto various mesoporous silicates nanoparticles by the wetness impregnation. The DSC results of indomethacin-loaded mesoporous silicates nanoparticles exhibited the amorphous state of drugs and thus might increase its dissolution and bioavailability. The release assays of indomethacin from these mesoporous silicates nanoparticles indicated that both the pore size and the surface functionalization of mesoporous silicates nanoparticles could affect their release rate. Furthermore, these indomethacin-loaded mesoporous silicates nanoparticles were entrapped into chitosan/alginate hydrogels and formed a series of hydrogel beads. The swelling studies indicated that the incorporation of mesoporous silicates nanoparticles had no influence on the swelling behaviors of hydrogel beads. The resultant beads displayed pH-sensitive and sustained-release of hydrophobic indomethacin and thus the combination of chitosan/alginate hydrogels and mesoporous silicates nanoparticles might serve as a potential oral hydrophobic drug delivery system.

Keywords

Hydrogels Mesoporous silicates Indomethacin pH-sensitive Sustained release
Deng, Z., Zhang, W., Lu, Y., Zhang, Y., Lu, Z., & Pei, S. (2014). Fabrication of Hydrogel Beads Entrappted by Mesoporous Silicates Nanoparticles for pH-sensitive and Sustained Release of Indomethacin. Asian Journal of Chemistry, 26(12), 3609–3614. https://doi.org/10.14233/ajchem.2014.16613
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