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Vol. 26 No. 12 (2014): Vol 26 Issue 12

Copyright (c) 2014 AJC

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Molecularly Imprinted Solid-Phase Extraction of Tetracyclines Residue from Milk Using Internal-Surface Reversed-Phase Hybrid Composite Packing Materials

https://doi.org/10.14233/ajchem.2014.16198
Yun-Kai Lv
College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Baoding 071002, P.R. China
Jing-Qi Zhang
College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Baoding 071002, P.R. China
Zhi-Yong Guo
College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Baoding 071002, P.R. China
Wen-Cai Wang
College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Baoding 071002, P.R. China
Bao-Hui Li
College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Baoding 071002, P.R. China

Corresponding Author(s) : Yun-Kai Lv

lvyunkai@hbu.edu.com

Asian Journal of Chemistry, Vol. 26 No. 12 (2014): Vol 26 Issue 12

Abstract

A novel internal-surface reversed-phase-molecularly imprinted polymer based on hybrid composite was developed for solid-phase extraction (SPE) of tetracyclines antibiotics from milk. The condition of loading, washing and eluting solvents in solid-phase extraction were investigated and evaluated by the recovery and retention of tetracyclines to obtain the optimum solid-phase extraction conditions. Under the optimal solid phase extraction conditions, three tetracyclines residues in milk were separated and detected by SPE-HPLC with better clean-up and enrichment. The mean recoveries of tetracycline antibiotics in milk were 85-106 % for tetracycline, 76-88 % for chlortetracycline and 90-94 % for doxycycline respectively, with relative standard deviations (RSDs) of 3.3-5.8%. The limits of detection (LOD, S/N = 3) and the limits of quantitation (LOQ, S/N = 10) of the proposed method were 10.4 and 34.7 mg kg-1 for tetracycline, 13.8 and 46 mg kg-1 for chlortetracycline and 7.5 and 25.1 mg kg-1 for doxycycline, respectively.

Keywords

Molecularly imprinted polymers Solid-phase extraction Hybrid composite materials Milk Tetracyclines
Lv, Y.-K., Zhang, J.-Q., Guo, Z.-Y., Wang, W.-C., & Li, B.-H. (2014). Molecularly Imprinted Solid-Phase Extraction of Tetracyclines Residue from Milk Using Internal-Surface Reversed-Phase Hybrid Composite Packing Materials. Asian Journal of Chemistry, 26(12), 3541–3544. https://doi.org/10.14233/ajchem.2014.16198
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