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Synthesis and Biological Evaluation of Novel Tetrahydroisoquinoline Derivatives as Antitumor Agents
Corresponding Author(s) : Shun Yao
Asian Journal of Chemistry,
Vol. 26 No. 12 (2014): Vol 26 Issue 12
Abstract
Fifteen novel tetrahydroisoquinoline derivatives have been synthesized via a mild synthetic route. The structures of all the compounds were confirmed by 1H NMR spectra, 13C NMR spectra and mass spectra. Their antitumor activities were evaluated in four human tumor cell lines, including human colon carcinoma (HCT116), non-small cell lung cancer (H1975), human lung adenocarcinoma (A549) and human pancreatic cancer (BxPC-3). Among them, compounds 4i and 4j exhibited remarkable growth inhibitory activity against the subtotal tested subpanel tumor cell lines particularly H1975 with GI values of 59.1 and 63.0 %, respectively.
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X.Y. Zhang, Z.J. Liu, B. Xu, Z.L. Sun, Y.Q. Gong and C.S. Shao, Eur. J. Pharmacol., 677, 47 (2012); doi:10.1016/j.ejphar.2011.12.035.
A. Burgeiro, A.C. Bento, C. Gajate, P.J. Oliveira and F. Mollinedo, Eur. J. Pharmacol., 705, 109 (2013); doi:10.1016/j.ejphar.2013.02.035.
H.R. Lin, M.K. Safo and D.J. Abraham, Bioorg. Med. Chem. Lett., 17, 2581 (2007); doi:10.1016/j.bmcl.2007.02.002.
Q.Q. Huang, L.H. Chen and F.J. Nan, Tetrahedron Lett., 49, 5141 (2008); doi:10.1016/j.tetlet.2008.06.094.
R.R. Kumar, S. Perumal, J.C. Menéndez, P. Yogeeswari and D. Sriram, Bioorg. Med. Chem., 19, 3444 (2011); doi:10.1016/j.bmc.2011.04.033.
K. Balamurugan, V. Jeyachandran, S. Perumal and J.C. Menéndez, Tetrahedron, 67, 1432 (2011); doi:10.1016/j.tet.2010.12.052.