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Vol. 26 No. 12 (2014): Vol 26 Issue 12

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Synthesis of Main Impurity of Vildagliptin

https://doi.org/10.14233/ajchem.2014.16018
Zhu Tao
College of Pharmaceutical Sciences, Chongqing Medical University, Chongqing 400016, P.R. China
Yu Deng
College of Pharmaceutical Sciences, Chongqing Medical University, Chongqing 400016, P.R. China
Yingjie Chen
College of Pharmaceutical Sciences, Chongqing Medical University, Chongqing 400016, P.R. China
Anmin Wang
College of Pharmaceutical Sciences, Chongqing Medical University, Chongqing 400016, P.R. China
Xiangnan Hu
College of Pharmaceutical Sciences, Chongqing Medical University, Chongqing 400016, P.R. China

Corresponding Author(s) : Xiangnan Hu

huxiangnan62@163.com

Asian Journal of Chemistry, Vol. 26 No. 12 (2014): Vol 26 Issue 12

Abstract

A four-step synthesis of the main impurity of vildagliptin has been easily accomplished with high-yielding starting from L-proline. This compound can be used as a reference marker in an analytical method to determine the chemical purity of the vildagliptin.

Keywords

DPP-IV inhibitors Vildagliptin L-proline Impurity
Tao, Z., Deng, Y., Chen, Y., Wang, A., & Hu, X. (2014). Synthesis of Main Impurity of Vildagliptin. Asian Journal of Chemistry, 26(12), 3489–3492. https://doi.org/10.14233/ajchem.2014.16018
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