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Vol. 26 No. 11 (2014): Vol 26 Issue 11

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Synthesis of New 2-(N'-Allylidene-hydrazino)quinazolinones and 2-(4,5-Dihydropyrazolyl)-quinazolinones and Their Antimicrobial and Antifungal Activity Screening

https://doi.org/10.14233/ajchem.2014.15880
Nezire Saygili
Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Hacettepe University, Sihhiye, 06100 Ankara, Turkey
Melike Ekizoglu
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Hacettepe University, Sihhiye, 06100 Ankara, Turkey
Ceren Erdogdu
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Hacettepe University, Sihhiye, 06100 Ankara, Turkey

Corresponding Author(s) : Nezire Saygili

nezires@hacettepe.edu.tr

Asian Journal of Chemistry, Vol. 26 No. 11 (2014): Vol 26 Issue 11

Abstract

Novel 2-[N'-(1,3-disubstituted-phenyl)allylidene]hydrazine-3-ethyl-3H-quinazolin-4-one (8) and 2-(3,5-disubstituted-phenyl-4,5-dihydro-pyrazol-1-yl)-3-ethyl-3H-quinazolin-4-one (9) compounds have been prepared and tested for antibacterial and antifungal activities. 1H NMR, 13C NMR, elemental analysis and mass spectroscopy methods have been used to identify molecular structures of the newly synthesized compounds. For screening antibacterial and antifungal activities of the new compounds, minimum inhibitory concentration (MIC) values were evaluated against the Staphylococcus aureus, Escherichia. coli, Pseudomonas aeruginosa, Enterococcus faecalis, Candida albicans, Candida parapsilosis and Candida krusei using microdilution broth method. Compounds 8a-8h exhibited the best antibacterial activity against E. faecalis.

Keywords

Activity Antifungal Antimicrobial Pyrazoline Quinazolinone Synthesis
Saygili, N., Ekizoglu, M., & Erdogdu, C. (2014). Synthesis of New 2-(N’-Allylidene-hydrazino)quinazolinones and 2-(4,5-Dihydropyrazolyl)-quinazolinones and Their Antimicrobial and Antifungal Activity Screening. Asian Journal of Chemistry, 26(11), 3197–3203. https://doi.org/10.14233/ajchem.2014.15880
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