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Vol. 26 No. 10 (2014): Vol 26 Issue 10

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Determination of Captopril by Using Phosphorus Molybdenum Blue as Spectral Probe Reagent

https://doi.org/10.14233/ajchem.2014.16531
Binglin Fan
School of Basic Medical Science, Xinxiang Medical University, Xinxiang 453003, Henan Province, P.R. China
Zhijun Yang
School of Basic Medical Science, Xinxiang Medical University, Xinxiang 453003, Henan Province, P.R. China
Wenxiao Zhu
Henan College of Traditional Chinese Medicine, Zhengzhou 450000, Henan Province, P.R. China
Zhenhua Yang
School of Basic Medical Science, Xinxiang Medical University, Xinxiang 453003, Henan Province, P.R. China
Quanmin Li
College of Chemistry and Environmental Science, Henan Normal University, The Key Laboratory of Environmental Pollution Control Technology of Henan province, Xinxiang 453007, Henan Province, P.R. China

Corresponding Author(s) : Binglin Fan

binglinfan2006@126.com

Asian Journal of Chemistry, Vol. 26 No. 10 (2014): Vol 26 Issue 10

Abstract

A novel method was established to determine captopril content by using phosphorus molybdenum blue as spectral probe reagent. The experiment indicated that PO43– reacted with [Mo7O24]6– in 0.30 mol/L H2SO4 solution to form a product of phosphorus-molybdenum heteropoly acid ([H2PMo12O40]–) which was reduced to phosphorus molybdenum blue (H3PO4·10 MoO3·Mo2O5) by captopril. The absorbance of phosphorus molybdenum blue was measured at the maximum absorption wavelength 730 nm and the amount of captopril could be determined based on this absorbance. A good linear relationship between absorbency and the concentration of captopril was in the range of 4.0-100.0 μg/mL and the regression equation was A = -0.01336 + 0.00504c (μg/mL) with a correlation coefficient 0.9992. The method had been successfully applied to the determination of captopril in pharmaceutical samples which the average recovery rate was in the range of 98.6-101 %.

Keywords

Phosphorus molybdenum blue Captopril Spectrophotometry
Fan, B., Yang, Z., Zhu, W., Yang, Z., & Li, Q. (2014). Determination of Captopril by Using Phosphorus Molybdenum Blue as Spectral Probe Reagent. Asian Journal of Chemistry, 26(10), 3025–3028. https://doi.org/10.14233/ajchem.2014.16531
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