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Vol. 26 No. 10 (2014): Vol 26 Issue 10

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Formation of Stable Palm Kernel Oil Esters Nanoemulsion System Containing Hydrocortisone

https://doi.org/10.14233/ajchem.2014.15929
Stephanie Da Costa
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia
Mahiran Basri
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia ;Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia
Norashikin Shamsudin
Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
Hamidon Basri
Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia

Corresponding Author(s) : Stephanie Da Costa

stephaniesharon@gmail.com

Asian Journal of Chemistry, Vol. 26 No. 10 (2014): Vol 26 Issue 10

Abstract

A physical and chemically stable palm kernel oil esters emulsion system with nanosized droplet was developed as a delivery system for hydrocortisone (hydrophobic drug). A simple low energy emulsification method was used in forming the nanoemulsions. The influence of added solvents (isopropanol and ethanol) on particle size and stability of oil in water nanoemulsion was investigated. Formation of nanoemulsion with solvent, increase the solubility of hydrocortisone in the oil phase and thus make the nanoemulsion more stable. Reducing the solvent to lipoid ratio showed no significant difference in the mean particle size. However, after solvent removal particle size increased over time. As for zeta potential value, all nanoemulsions exhibited values below -30 mV which indicated good stability. The DSC thermograms for stable nanoemulsions proved that hydrocortisone is in a non-crystalline state, suggesting that hydrocortisone is homogenized well in the nanoemulsion system. These results showed that nanoemulsion with solvent appear to be a promising transdermal delivery vehicle for hydrocortisone.

Keywords

Oil in water nanoemulsion Transdermal Solvent Binary surfactant Isopropanol Ethanol Hydrocortisone
Da Costa, S., Basri, M., Shamsudin, N., & Basri, H. (2014). Formation of Stable Palm Kernel Oil Esters Nanoemulsion System Containing Hydrocortisone. Asian Journal of Chemistry, 26(10), 2883–2888. https://doi.org/10.14233/ajchem.2014.15929
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