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Vol. 26 No. 10 (2014): Vol 26 Issue 10

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Extractive Spectrophotometric for Determination of Dihydroergocryptine Mesylate in Pharmaceutical Preparations

https://doi.org/10.14233/ajchem.2014.15828
Malek Okdeh
Department of Chemistry, Faculty of Science, Teshreen University, Lattakia, Syria
Amir Alhaj Sakur
Department of Analytical and Food Chemistry, Faculty of Pharmacy, Aleppo University, Aleppo, Syria
Banana Alfares
Department of Chemistry, Faculty of Science, Teshreen University, Lattakia, Syria

Corresponding Author(s) : Malek Okdeh

dr.malekokdeh@yahoo.com

Asian Journal of Chemistry, Vol. 26 No. 10 (2014): Vol 26 Issue 10

Abstract

Simple, accurate and highly sensitive spectrophotometric method has been developed for the rapid determination of dihydroergocryptine mesylate in pure form and pharmaceutical formulations. The spectrophotometric method was based on the formation of binary complex (ion-pair complex) between the dihydroergocryptine mesylate and chromotrope 2R in acidic buffer, giving purple color. The absorbance of dichloromethane extracted complex was measured at 531 nm. The effects of analytical parameters on the reported systems were investigated. The complexation reaction was extremely rapid at room temperature and the absorption value remains unchanged up to 24 h. Beer's law was obeyed in the concentration ranges of 3-180 μg/mL, detection limit was 0.08 μg/mL and the molar absorptivity coefficient were 6.8 × 103 L mol-1 cm-1 for chromotrope 2R. Recoveries were between 97.20-101.11 %. Interferences of the other ingredients and excipients were not observed.

Keywords

Extractive spectrophotometry Complex formation Dihydroergocryptine mesylate Chromotrope 2R
Okdeh, M., Alhaj Sakur, A., & Alfares, B. (2014). Extractive Spectrophotometric for Determination of Dihydroergocryptine Mesylate in Pharmaceutical Preparations. Asian Journal of Chemistry, 26(10), 2857–2860. https://doi.org/10.14233/ajchem.2014.15828
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