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Effect of Viscosity on Formulation of Olive Oil Nanoemulsion Using Ultrasonicator
Corresponding Author(s) : C.H. Anjali
Asian Journal of Chemistry,
Vol. 26 No. 9 (2014): Vol 26 Issue 9
Abstract
Olive oil has been reported to have many medicinal properties and it forms an important constituent of human diet. The efficacy of olive oil for drug delivery can be improved by the formulation of nanoemulsion. The present work focuses on olive oil nanoemulsion formulation using non ionic surfactant Tween 20 and co surfactant ethanol. Olive oil nanoemulsions have been successfully prepared mechanically by high energy sonicator. The physical state of the nanoemulsion is represented using pseudo ternary phase diagram. Concentration of oil, surfactant and co surfactant is optimized to obtain nanoemulsion of small size. The obtained nanoemulsion is checked for its stability and other characteristics like pH, particle size and viscosity. Viscosity of the nanoemulsion increased with increasing concentration of Tween 20. Surface morphology is observed using transmission electron microscopy. This study paved the way for development of a novel nanoemulsion for various applications.
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- P. Shah, D. Bhalodia and P. Shelat, Syst. Rev. Pharm., 1, 24 (2010); doi:10.4103/0975-8453.59509.
- G. Mustafa, Z. Khan, T. Bansal and S. Talegaonkar, Curr. Nanosci., 5, 428 (2009); doi:10.2174/157341309789377989.
- U. Wahrburg, M. Kratz and P. Cullen, Eur. J. Lipid Sci. Technol., 104, 698 (2002); doi:10.1002/1438-9312(200210)104:9/10<698::AID-EJLT698>3.0.CO;2-A.
- F. Visioli, A. Poli and C. Gall, Med. Res. Rev., 22, 65 (2002); doi:10.1002/med.1028.
- R.W. Owen, R. Haubner, G. Wurtele, W.E. Hull, B. Spiegelhalder and H. Bartsch, Eur. J. Cancer Prev., 13, 319 (2004); doi:10.1097/01.cej.0000130221.19480.7e.
- P. Dais and E. Hatzakis, Anal. Chim. Acta, 765, 1 (2013); doi:10.1016/j.aca.2012.12.003.
- Y. Oi-Kano, T. Kawada, T. Watanabe, F. Koyama, K. Watanabe, R. Senbongi and K. Iwai, J. Nutr. Biochem., 18, 685 (2007); doi:10.1016/j.jnutbio.2006.11.009.
- Z.-G. Gao, H.-G. Choi, H.-J. Shin, K.-M. Park, S.-J. Lim, K.-J. Hwang and C.-K. Kim, Int. J. Pharm., 161, 75 (1998); doi:10.1016/S0378-5173(97)00325-6.
- Z. Gao, H. Choi, H. Shin, K. Park, S. Lim, K. Hwang and C. Kim, Int. J. Pharm., 161, 75 (1998); doi:10.1016/S0378-5173(97)00325-6.
- T. Tadros, P. Izquierdo, J. Esquena and C. Solans, Adv. Colloid Interf., 108-109, 303 (2004); doi:10.1016/j.cis.2003.10.023.
- D.I.D. El Eini, B.W. Barry and C.T. Rhodes, J. Colloid Interf. Sci., 54, 348 (1976); doi:10.1016/0021-9797(76)90314-3.
References
P. Shah, D. Bhalodia and P. Shelat, Syst. Rev. Pharm., 1, 24 (2010); doi:10.4103/0975-8453.59509.
G. Mustafa, Z. Khan, T. Bansal and S. Talegaonkar, Curr. Nanosci., 5, 428 (2009); doi:10.2174/157341309789377989.
U. Wahrburg, M. Kratz and P. Cullen, Eur. J. Lipid Sci. Technol., 104, 698 (2002); doi:10.1002/1438-9312(200210)104:9/10<698::AID-EJLT698>3.0.CO;2-A.
F. Visioli, A. Poli and C. Gall, Med. Res. Rev., 22, 65 (2002); doi:10.1002/med.1028.
R.W. Owen, R. Haubner, G. Wurtele, W.E. Hull, B. Spiegelhalder and H. Bartsch, Eur. J. Cancer Prev., 13, 319 (2004); doi:10.1097/01.cej.0000130221.19480.7e.
P. Dais and E. Hatzakis, Anal. Chim. Acta, 765, 1 (2013); doi:10.1016/j.aca.2012.12.003.
Y. Oi-Kano, T. Kawada, T. Watanabe, F. Koyama, K. Watanabe, R. Senbongi and K. Iwai, J. Nutr. Biochem., 18, 685 (2007); doi:10.1016/j.jnutbio.2006.11.009.
Z.-G. Gao, H.-G. Choi, H.-J. Shin, K.-M. Park, S.-J. Lim, K.-J. Hwang and C.-K. Kim, Int. J. Pharm., 161, 75 (1998); doi:10.1016/S0378-5173(97)00325-6.
Z. Gao, H. Choi, H. Shin, K. Park, S. Lim, K. Hwang and C. Kim, Int. J. Pharm., 161, 75 (1998); doi:10.1016/S0378-5173(97)00325-6.
T. Tadros, P. Izquierdo, J. Esquena and C. Solans, Adv. Colloid Interf., 108-109, 303 (2004); doi:10.1016/j.cis.2003.10.023.
D.I.D. El Eini, B.W. Barry and C.T. Rhodes, J. Colloid Interf. Sci., 54, 348 (1976); doi:10.1016/0021-9797(76)90314-3.