Issue

Vol. 31 No. 4 (2019): Vol 31 Issue 4

Copyright (c) 2019 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Thermal Characterization and in vitro Antibacterial Assessment of Co(II) and Cd(II) Complexes of Schiff Base Derived from Amoxicillin and Thiophene-2-carbaldehyde

https://doi.org/10.14233/ajchem.2019.21882
N.K. Chaudhary*
Bio-inorganic and Materials Chemistry Research Laboratory, Mahendra Morang Adarsh Multiple Campus, (Tribhuvan University), Biratnagar, Nepal *Corresponding author: E-mail: chem_narendra@yahoo.com
B. Guragain
Bio-inorganic and Materials Chemistry Research Laboratory, Mahendra Morang Adarsh Multiple Campus, (Tribhuvan University), Biratnagar, Nepal *Corresponding author: E-mail: chem_narendra@yahoo.com

Asian Journal of Chemistry, Vol. 31 No. 4 (2019): Vol 31 Issue 4

Abstract

A novel AMXTC2 ligand was prepared by simultaneous stirring and refluxing of an equimolar mixture of amoxicillin and thiophene-2-carbaldehyde in methanol and was further used to synthesize metal complexes by metalation with cobalt and cadmium salts, taking ligand metal ratio 2:1. They were characterized by elemental microanalysis, FT-IR, mass, UV-visible, 1H NMR, thermal analysis, magnetic moment and molar conductance measurements. The coordination sites in the ligand were verified by their comparative and extensive spectral studies. The detailed exploration of the data suggested octahedral geometry for Co-AMXTC2 and tetrahedral geometry for Cd-AMXTC2 complexes. The thermodynamic and kinetic parameters such as E*, ΔH*, ΔS* and ΔG* of various decomposition steps were calculated from TGA curves using the Coats-Redfern method. The molar conductivity data suggested non-electrolytic nature of the complexes. SEM analysis was done to observe their surface morphology. The geometry optimization of the proposed molecular structure of the complexes was achieved by running MM2 calculation in Gaussian supported Cs-ChemOffice Ultra-11 program software. The biological activities had been evaluated in vitro against E. coli, K. pneumonia, P. vulgaris and S. aureus pathogens in order to assess their antibacterial potency. The biological data revealed better growth inhibitory action of the ligand and metal complexes with bacterial pathogens.

Keywords

Amoxicillin Thiophene-2-carbaldehyde Schiff base Thermal study Antibacterial activity.
Chaudhary*, N., & Guragain, B. (2019). Synthesis, Thermal Characterization and in vitro Antibacterial Assessment of Co(II) and Cd(II) Complexes of Schiff Base Derived from Amoxicillin and Thiophene-2-carbaldehyde. Asian Journal of Chemistry, 31(4), 951–959. https://doi.org/10.14233/ajchem.2019.21882
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. S.B. Zaman, M.A. Hussain, R. Nye, V. Mehta, K.T. Mamun and N. Hossain, Cureus, 9, e1403 (2017); https://doi.org/10.7759/cureus.1403.
  2. F. Prestinaci, P. Pezzotti and A. Pantosti, Pathog. Glob. Health, 109, 309 (2015); https://doi.org/10.1179/2047773215Y.0000000030.
  3. A. Franceschi, M. Tuccori, G. Bocci, F. Vannozzi, A. Di Paolo, C. Barbara, M. Lastella, C. Blandizzi and M. Del Tacca, Pharmacol. Res., 49, 85 (2004); https://doi.org/10.1016/j.phrs.2003.08.001.
  4. J.R. Anacona, K. Mago and J. Camus, Appl. Organomet. Chem., 32, e4374 (2018); https://doi.org/10.1002/aoc.4374.
  5. M.A. Malik, O.A. Dar, P. Gull, M.Y. Wani and A.A. Hashmi, MedChemComm, 9, 409 (2018); https://doi.org/10.1039/C7MD00526A.
  6. A.N. Srivastva, N.P. Singh and C.K. Shriwastaw, Arab. J. Chem., 9, 48 (2016); https://doi.org/10.1016/j.arabjc.2014.10.004.
  7. R. Jin, J. Liu, G. Zhang, J. Li, S. Zhang and H. Guo, Chem. Biodivers., 15, e1800263 (2018); https://doi.org/10.1002/cbdv.201800263.
  8. R. Miyazaki, H. Yasui and Y. Yoshikawa, Open J. Inorg. Chem., 6, Article ID 65425 (2016); https://doi.org/10.4236/ojic.2016.62007.
  9. S. Murtaza, M.S. Akhtar, F. Kanwal, A. Abbas, S. Ashiq and S. Shamim, J. Saudi Chem. Soc., 21, S359 (2017); https://doi.org/10.1016/j.jscs.2014.04.003.
  10. N. Mohammed Hosny, Y.E. Sherif and A.A. El-Rahman, J. Coord. Chem., 61, 2536 (2008); https://doi.org/10.1080/00958970801930047.
  11. H. Luo, Y.F. Xia, B.F. Sun, L.R. Huang, X.H. Wang, H.Y. Lou, X.H. Zhu, W.D. Pan and X.D. Zhang, Biochem. Res. Int., 2017, 1 (2017); https://doi.org/10.1155/2017/6257240.
  12. A. Aouniti, H. Elmsellem, S. Tighadouini, M. Elazzouzi, S. Radi, A. Chetouani, B. Hammouti and A. Zarrouk, J. Taibah Univ. Sci., 10, 774 (2016); https://doi.org/10.1016/j.jtusci.2015.11.008.
  13. Y. Jia and J. Li, Chem. Rev., 115, 1597 (2015); https://doi.org/10.1021/cr400559g.
  14. E.A. Lane, M.J. Canty and S.J. More, Res. Vet. Sci., 101, 132 (2015); https://doi.org/10.1016/j.rvsc.2015.06.004.
  15. L. Izrael-Zivkovic, M. Rikalovic, G. Gojgic-Cvijovic, S. Kazazic, M. Vrvic, I. Brèeski, V. Beskoski, B. Lonèarevic, K. Gopèevic and I. Karad•ic, RSC Adv., 8, 10549 (2018); https://doi.org/10.1039/C8RA00371H.
  16. S.G. Teoh, S.H. Ang, H.K. Fun and C.W. Ong, J. Organomet. Chem., 580, 17 (1999); https://doi.org/10.1016/S0022-328X(98)01099-7.
  17. N.K. Chaudhary and P. Mishra, J. Saudi Chem. Soc., 22, 601 (2018); https://doi.org/10.1016/j.jscs.2017.10.003.
  18. N.K. Chaudhary and P. Mishra, Bioinorg. Chem. Appl., 2017, Article ID 6927675 (2017); https://doi.org/10.1155/2017/6927675.
  19. K. Dhahagani, S. Mathan Kumar, G. Chakkaravarthi, K. Anitha, J. Rajesh, A. Ramu and G. Rajagopal, Spectrochim. Acta A Mol. Biomol. Spectrosc., 117, 87 (2014); https://doi.org/10.1016/j.saa.2013.07.101.
  20. A.W. Bauer, W.M.M. Kirby, J.C. Sherris and M. Turck, Am. J. Clin. Pathol., 45(4_ts), 493 (1966); https://doi.org/10.1093/ajcp/45.4_ts.493.
  21. G.N. Rolinson and E.J. Russell, Antimicrob. Agents Chemother., 2, 51 (1972); https://doi.org/10.1128/AAC.2.2.51.
  22. G.G. Mohamed, M. Zayed and S.M. Abdallah, J. Mol. Struct., 979, 62 (2010); https://doi.org/10.1016/j.molstruc.2010.06.002.
  23. M.S. Nair, D. Arish and R.S. Joseyphus, J. Saudi Chem. Soc., 16, 83 (2012); https://doi.org/10.1016/j.jscs.2010.11.002.
  24. J.P. Coates, A Practical Approach to the Interpretation of Infrared Spectra, In: Encyclopedia of Analytical Chemistry. John Wiley & Sons Ltd.: Chichester, pp. 10815–10837 (2000).
  25. H.S. Seleem, Chem. Cent. J., 5, 35 (2011); https://doi.org/10.1186/1752-153X-5-35.
  26. F. Rahaman and B.H.M. Mruthyunjayaswamy, Complex Met., 1, 88(2014); https://doi.org/10.1080/2164232X.2014.889580.
  27. L.A. Saghatforoush, A. Aminkhani, S. Ershad, G. Karimnezhad, S. Ghammamy and R. Kabiri, Molecules, 13, 804 (2008); https://doi.org/10.3390/molecules13040804.
  28. C.M. Sharaby, Biomol. Spectrosc., 66, 1271 (2007); https://doi.org/10.1016/j.saa.2006.05.030.
  29. M. Sedighipoor, A.H. Kianfar, M.R. Sabzalian and F. Abyar, Spectrochim. Acta A: Mol. Biomol. Spectrosc., 198, 38 (2018); https://doi.org/10.1016/j.saa.2018.02.050.
  30. N.C. Ii, N. Ii, C. Ii, G. Ahumada, M. Fuentealba, T. Roisnel, S. Kahlal, D. Carrillo, R. Cordova, J. Saillard, J. Hamon and C. Manzur, Polyhedron, 151, 279 (2018); https://doi.org/10.1016/j.poly.2018.05.048.
  31. R. Ebrahimi-Kahrizsangi and M.H. Abbasi, Trans. Nonferr. Met. Soc. China, 18, 217 (2008); https://doi.org/10.1016/S1003-6326(08)60039-4.
  32. A. Coats and J.P. Redfern, Analyst, 88, 906 (1963); https://doi.org/10.1039/an9638800906.
  33. M. Montazerozohori, S. Zahedi, A. Naghiha and M.M. Zohour, Mater. Sci. Eng. C, 35, 195 (2014); https://doi.org/10.1016/j.msec.2013.10.030.
  34. P. Raj, A. Singh, A. Singh, N. Singh, Sustain. Chem. Eng., (2017). https://doi.org/10.1021/acssuschemeng.7b00963.
  35. G. Sirikci, N.A. Ancin and S.G. Öztas, J. Mol. Model., 21, 221 (2015); https://doi.org/10.1007/s00894-015-2764-4.
  36. P. Mendu, J. Pragathi, B. Anupama and C.G. Kumari, E-J. Chem., 9, 2145 (2012); https://doi.org/10.1155/2012/839789.
  37. M. Padmaja, J. Pragathi, C.G. Kumari and A. Pradesh, J. Chem. Pharm. Res., 3, 602 (2011).
  38. S.S. Panda, O.S. Detistov, A.S. Girgis, P.P. Mohapatra, A. Samir and A.R. Katritzky, Bioorg. Med. Chem. Lett., 26, 2198 (2016); https://doi.org/10.1016/j.bmcl.2016.03.062.
  39. N. Fey, J. Chem. Technol. Biotechnol., 74, 852 (1999); https://doi.org/10.1002/(SICI)1097-4660(199909)74:9<852::AIDJCTB131>3.0.CO;2-T.
  40. A.M. Majcher, P. Dabczyñski, M.M. Marzec, M. Ceglarska, J. Rysz, A. Bernasik, S. Ohkoshi and O. Stefañczyk, Chem. Sci., 9, 7277 (2018); https://doi.org/10.1039/C8SC02277A.
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 0 Download : 0