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Vol. 34 No. 5 (2022): Vol 34 Issue 5, 2022

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Synthesis of Novel Oxazolidinone Derivatives Bearing Benzo[b]thiophene Moiety and their Antimicrobial Evaluation

https://doi.org/10.14233/ajchem.2022.23633
Mukunda R. Patekar
Chemistry Research Centre, P.G. Department of Chemistry, K.T.H.M. College (Affiliated to Savitribai Phule Pune University, Pune), Gangapur Road, Nashik-422002, India
Ghanshyam R. Jadhav
Chemistry Research Centre, P.G. Department of Chemistry, K.T.H.M. College (Affiliated to Savitribai Phule Pune University, Pune), Gangapur Road, Nashik-422002, India
Dattatray G. Deshmukh
Chemistry Research Centre, P.G. Department of Chemistry, K.T.H.M. College (Affiliated to Savitribai Phule Pune University, Pune), Gangapur Road, Nashik-422002, India
Vijay J. Medhane
Chemistry Research Centre, P.G. Department of Chemistry, K.T.H.M. College (Affiliated to Savitribai Phule Pune University, Pune), Gangapur Road, Nashik-422002, India ; Department of Chemistry, S.V.K.T. College (Affiliated to Savitribai Phule Pune University, Pune), Deolali Camp, Nashik-422401, India

Corresponding Author(s) : Vijay J. Medhane

vjmedhane1664@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 5 (2022): Vol 34 Issue 5, 2022

Abstract

Literature survey revealed that the oxazolidinone derivatives exhibit pharmacological significance. Thus, by targeting to design new antimicrobial agent, a novel series of oxazolidinone derivatives (11a-t) having benzo[b]thiophene moiety were synthesized. Chemical structures of the synthesized compounds were confirmed through spectroscopic techniques such as IR, NMR and Mass spectroscopy. All the new synthesized compounds were subjected to in vitro antimicrobial testing by estimating zone of inhibition toward Gram-positive pathogens like Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 25923 and Streptococcus pyogens ATCC 8668.

Keywords

Oxazolidinone Benzo[b]thiophene Linezolid Antimicrobial activity
R. Patekar, M., R. Jadhav, G., G. Deshmukh, D., & J. Medhane, V. (2022). Synthesis of Novel Oxazolidinone Derivatives Bearing Benzo[b]thiophene Moiety and their Antimicrobial Evaluation. Asian Journal of Chemistry, 34(5), 1197–1205. https://doi.org/10.14233/ajchem.2022.23633
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